Icahn School of Medicine at Mount Sinai, New York, New York, USA.
University of California, San Francisco, San Francisco, California, USA.
J Infect Dis. 2021 Feb 13;223(3):403-408. doi: 10.1093/infdis/jiaa380.
We performed a retrospective study of coronavirus disease 2019 (COVID-19) in people with human immunodeficiency virus (PWH). PWH with COVID-19 demonstrated severe lymphopenia and decreased CD4+ T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin 6, interleukin 8, and tumor necrosis factor α were commonly elevated. In all, 19 of 72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of COVID-19 despite antiretroviral therapy and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.
我们对人类免疫缺陷病毒（HIV）感染者（PWH）的 2019 年冠状病毒病（COVID-19）进行了回顾性研究。COVID-19 患者表现出严重的淋巴细胞减少和 CD4+ T 细胞计数下降。炎症标志物水平，包括 C 反应蛋白、纤维蛋白原、D-二聚体、白细胞介素 6、白细胞介素 8 和肿瘤坏死因子 α 通常升高。在 72 名住院患者中，共有 19 人（26.4%）死亡，53 人（73.6%）康复。死亡的 HIV 感染者的炎症标志物水平和更严重的淋巴细胞减少比康复的 HIV 感染者更高。这些发现表明，尽管接受了抗逆转录病毒治疗，HIV 感染者仍然存在 COVID-19 严重表现的风险，而那些炎症和免疫失调标志物升高的患者则有更糟糕的结局风险。
