Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
The Blood Purification Center, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Psychopharmacology (Berl). 2020 Sep;237(9):2739-2752. doi: 10.1007/s00213-020-05569-x. Epub 2020 Jun 30.
Although a growing body of evidence indicates that the scores of cognitive function in hemodialysis patients are significantly lower than those of healthy individuals, underlying mechanisms have not been fully elucidated.
To investigate the roles of gut microbiota and serum metabolites in hemodialysis patients with mild cognitive decline (MCD).
A total of 30 healthy individuals and 77 hemodialysis patients were enrolled and were classified into healthy control (HC), normal cognitive function (NCF), and MCD groups by evaluation of Montreal Cognitive Assessment. Fecal samples were analyzed by 16S rRNA and serum samples were analyzed by gas chromatography-mass spectrometry from all subjects.
The 16S rRNA study demonstrated that the gut microbiota profiles, including α- and β-diversity, and a number of 16 gut bacteria were significantly altered in the MCD group compared with those in HC or those with NCF. A metabonomics study showed that a total of 29 serum metabolites were altered in the MCD group. Receiver operating characteristic curves showed that Genus Bilophila and serum putrescine might be sensitive biomarkers to indicate MCD in patients with hemodialysis.
These findings demonstrate gut microbiota and serum metabolites were probably involved in the pathogenesis of hemodialysis-related MCD. Therapeutic strategies targeting abnormalities in gut microbiota and serum metabolites may facilitate the beneficial effects for hemodialysis patients with MCD.
越来越多的证据表明，血液透析患者的认知功能评分明显低于健康个体，但潜在机制尚未完全阐明。
探讨肠道微生物群和血清代谢物在血液透析轻度认知障碍（MCD）患者中的作用。
共纳入 30 名健康个体和 77 名血液透析患者，通过蒙特利尔认知评估对所有患者进行评估，分为健康对照组（HC）、正常认知功能组（NCF）和 MCD 组。对所有受试者的粪便样本进行 16S rRNA 分析，血清样本进行气相色谱-质谱分析。
16S rRNA 研究表明，与 HC 或 NCF 相比，MCD 组的肠道微生物群谱（包括α和β多样性）和许多 16 种肠道细菌发生了显著改变。代谢组学研究表明，MCD 组共有 29 种血清代谢物发生改变。受试者工作特征曲线表明，属双歧杆菌和血清腐胺可能是血液透析患者 MCD 的敏感生物标志物。
这些发现表明，肠道微生物群和血清代谢物可能参与了血液透析相关 MCD 的发病机制。针对肠道微生物群和血清代谢物异常的治疗策略可能有助于改善血液透析 MCD 患者的疗效。
