Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
The Blood Purification Center, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Sci Rep. 2018 Aug 16;8(1):12250. doi: 10.1038/s41598-018-29760-5.
Studies suggest that hemodialysis patients are at a higher risk for cognitive decline than healthy individuals; however, underlying mechanisms have not been fully elucidated. We aimed to investigate the roles of serum biomarkers, such as brain-derived neurotrophic factor (BDNF), inflammatory cytokines, fibroblast growth factor (FGF)-23 and its co-receptor α-klotho and platelet (PLT) count in mild cognitive decline (MCD) of patients undergoing hemodialysis in this prospective cohort study. Serum levels of BDNF, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and the number of PLT were significantly altered in the MCD group compared with those in healthy controls (HCs) or those with normal cognitive function (NCF). Although serum α-klotho and FGF-23 levels were significantly altered in the MCD group, there were no statistical differences between the MCD and NCF groups. Serum BDNF levels and PLT counts were significantly correlated with cognitive test scores. Receiver operating characteristic (ROC) curves demonstrated that BDNF and PLT were potential biomarkers for improved MCD diagnosis in patients with hemodialysis. These findings suggest that hemodialysis-related MCD is associated with altered BDNF, TNF-α and IL-6 levels as well as PLT counts and that serum BDNF levels and PLT counts are potential biomarkers for hemodialysis-related MCD diagnosis.
研究表明，血液透析患者的认知能力下降风险高于健康人群；然而，其潜在机制尚未完全阐明。我们旨在通过前瞻性队列研究，探讨血清生物标志物如脑源性神经营养因子（BDNF）、炎症细胞因子、成纤维细胞生长因子（FGF）-23及其共同受体α-klotho 和血小板（PLT）计数在血液透析患者轻度认知障碍（MCD）中的作用。与健康对照组（HCs）或认知功能正常（NCF）组相比，MCD 组的血清 BDNF、肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6 水平和 PLT 数量显著改变。尽管 MCD 组的血清 α-klotho 和 FGF-23 水平显著改变，但 MCD 组与 NCF 组之间无统计学差异。血清 BDNF 水平和 PLT 计数与认知测试评分显著相关。受试者工作特征（ROC）曲线表明，BDNF 和 PLT 是血液透析患者改善 MCD 诊断的潜在生物标志物。这些发现表明，与血液透析相关的 MCD 与 BDNF、TNF-α 和 IL-6 水平以及 PLT 计数的改变有关，血清 BDNF 水平和 PLT 计数是血液透析相关 MCD 诊断的潜在生物标志物。
