Suzuki Rikio, Kawai Hidetsugu, Furuya Daisuke, Akashi Hibiki, Ogawa Yoshiaki, Kawada Hiroshi, Ando Kiyoshi
Department of Hematology/Oncology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Tokai J Exp Clin Med. 2020 Jul 20;45(2):92-96.
A 69-year-old man was referred to the hematology department for the evaluation of pancytopenia. He had been treated with radiation and epirubicin for hepatocellular carcinoma, and with docetaxel and pembrolizumab for lung adenocarcinoma. Bone marrow smears exhibited markedly increased promyelocytes, and polymerase chain reaction (PCR) study demonstrated chimeric fusion genes of . He was diagnosed with therapy-related acute promyelocytic leukemia (t-APL) and treated with all trans-retinoic acid (ATRA). After 30 days of ATRA treatment, complete hematological response was achieved. To the best of our knowledge, this case represents the first description of successfully treated t-APL diagnosed after treatment with pembrolizumab.
一名69岁男性因全血细胞减少被转诊至血液科。他曾接受过针对肝细胞癌的放疗和表柔比星治疗，以及针对肺腺癌的多西他赛和帕博利珠单抗治疗。骨髓涂片显示早幼粒细胞显著增多，聚合酶链反应（PCR）研究证实了嵌合融合基因。他被诊断为治疗相关的急性早幼粒细胞白血病（t-APL），并接受了全反式维甲酸（ATRA）治疗。ATRA治疗30天后，实现了完全血液学缓解。据我们所知，该病例是首例关于帕博利珠单抗治疗后诊断出的t-APL成功治疗的描述。
