Kovar I Z, Riches P G
Department of Child Health, Charing Cross and Westminster Medical School, London.
J Clin Pathol. 1988 Jun;41(6):650-2. doi: 10.1136/jcp.41.6.650.
To determine whether changes in complement or acute phase proteins can predict onset of labour, complement components C3 and C4, alpha-1-antitrypsin, and alpha-1-acid glycoprotein were measured serially in the third trimester of pregnancy and throughout labour in 11 women. C-reactive protein (CRP) concentration, C3 conversion products, and factor B activation was studied in five pregnancies one week before delivery, during labour, and six weeks after delivery. C3, C4, and CRP concentrations were unchanged and there was no evidence of complement conversion, either immediately before or during labour, by the classical or alternative pathways. A wide variation among subjects but a small variation within subjects for all proteins assayed was noted. It is important to use serial rather than cross sectional biochemical data when determining normal physiological patterns in pregnancy. The proteins measured have no predictive value in the timing of the onset of normal labour.
为了确定补体或急性期蛋白的变化是否能够预测分娩发动，对11名女性在妊娠晚期及整个分娩过程中连续测定补体成分C3和C4、α1抗胰蛋白酶以及α1酸性糖蛋白。对5例妊娠在分娩前1周、分娩期间及分娩后6周研究了C反应蛋白（CRP）浓度、C3转化产物及B因子激活情况。C3、C4和CRP浓度未发生变化，且在分娩前或分娩期间均无经典途径或替代途径补体转化的证据。在所检测的所有蛋白质中，观察到个体间差异较大但个体内差异较小。在确定妊娠正常生理模式时，使用连续而非横断面生化数据很重要。所检测的蛋白质对正常分娩发动时间没有预测价值。
