一种高效、简便的异喹啉和杂芳烃三氟甲基化和全氟烷基化的策略。
An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes.
机构信息
Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China.
出版信息
Chem Commun (Camb). 2020 Jul 14;56(56):7813-7816. doi: 10.1039/d0cc00963f.
PMID:32602495
Abstract
An effective and regioselective strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes was developed. By combination of TMSCnF2n+1 (n = 1, 2, 3) with PIFA, the method achieved the corresponding perfluoroalkylated products with broad functional group tolerance.
摘要
发展了一种有效且区域选择性的异喹啉和杂芳烃三氟甲基化和全氟烷基化策略。通过 TMSCnF2n+1（n = 1、2、3）与 PIFA 的组合，该方法实现了具有广泛官能团容忍度的相应全氟烷基化产物。
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