Li Dawei, Wang Sijing, Ge Shulin, Dong Shunxi, Feng Xiaoming
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
Org Lett. 2020 Jul 17;22(14):5331-5336. doi: 10.1021/acs.orglett.0c01581. Epub 2020 Jun 30.
A highly atroposelective -acylation reaction of aniline-derived sulfonamides has been developed with chiral isothiourea as the catalyst. This approach provides a facile and efficient route to an array of atropoisomeric sulfonyl substituted anilide products in good yields with high to excellent enantioselectivities.
以手性异硫脲为催化剂，开发了一种苯胺衍生磺酰胺的高对映选择性酰化反应。该方法提供了一条简便有效的途径，可高产率地得到一系列轴手性磺酰基取代苯胺类产物，对映选择性高至优异。
