Pittschieler K, Reissigl H, Mengarda G
Department of Pediatrics, Regional Hospital, Bozen-Bolzano, Italy.
J Pediatr Gastroenterol Nutr. 1988 May-Jun;7(3):400-2. doi: 10.1097/00005176-198805000-00014.
The expression of celiac disease is assumed to be influenced by both genetic and environmental factors. Our study investigated the prevalence and HLA type in two different ethnic groups: a German group and an Italian group living in South Tirol. Intermarriages are rare between these population groups. The live birth rate during 1973-1982 (10 years) was 42,739 for the German group and 14,874 for the Italian group. Fifty people with celiac disease, born during this period, were diagnosed according to the ESPGAN criteria: 45 were German and five were Italian. The incidence in the German group was 105 per 100,000, and 33 per 100,000 in the Italian group. HLA typing was performed in 40 patients, and in 50 German and 50 Italian controls. Of the patients with celiac disease, 43% were positive for HLA B8, 85% for DR3, and 66% for DR7. Although lower, no difference was found in the expression of HLA B8, DR3, and DR7 in the Italian and German controls. The data presented here strongly suggest that there is little association between the incidence of the disease and HLA type in the two ethnic populations. However, from preliminary data, it is postulated that the age of the infant when gluten is added to its diet will affect the incidence of celiac disease.
乳糜泻的发病被认为受遗传和环境因素的双重影响。我们的研究调查了两个不同种族群体中的患病率和HLA类型：一个是德国群体，另一个是生活在南蒂罗尔的意大利群体。这些人群之间的通婚很少见。1973年至1982年（10年）期间，德国群体的活产率为42739例，意大利群体为14874例。在此期间出生的50名乳糜泻患者根据ESPGAN标准被诊断出来：45名是德国人，5名是意大利人。德国群体的发病率为每10万人中有105例，意大利群体为每10万人中有33例。对40例患者以及50名德国和50名意大利对照者进行了HLA分型。在乳糜泻患者中，43%的人HLA B8呈阳性，85%的人DR3呈阳性，66%的人DR7呈阳性。虽然比例较低，但在意大利和德国对照者中，HLA B8、DR3和DR7的表达没有差异。此处呈现的数据强烈表明，在这两个人种群体中，该病的发病率与HLA类型之间几乎没有关联。然而，根据初步数据推测，婴儿饮食中添加麸质时的年龄会影响乳糜泻的发病率。
