Trabace S, Giunta A, Rosso M, Marzorati D, Cascino I, Tettamanti A, Mazzilli M C, Gandini E
Vox Sang. 1984;46(2):102-6. doi: 10.1111/j.1423-0410.1984.tb00059.x.
HLA phenotypes of 64 Italian pediatric patients with celiac disease (CD) were compared with those of a group of healthy controls. DR3 and DR7 are significantly increased as reported in other populations. In addition an increase of heterozygotes DR5/DR7 was observed in our patients. The Hardy-Weinberg distribution in the patients group shows a disequilibrium due to the genotype DR5/DR7. Our data confirm that more than one HLA gene product is associated with CD: one with DR3 and the other with DR7.
将64名意大利乳糜泻（CD）儿科患者的HLA表型与一组健康对照者的HLA表型进行了比较。如在其他人群中所报道的，DR3和DR7显著增加。此外，在我们的患者中观察到杂合子DR5/DR7有所增加。患者组中的哈迪-温伯格分布显示由于基因型DR5/DR7而出现失衡。我们的数据证实，不止一种HLA基因产物与乳糜泻相关：一种与DR3相关，另一种与DR7相关。
