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Arch Dis Child. 1995 Jan;72(1):29-32. doi: 10.1136/adc.72.1.29.
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Transient gluten intolerance.短暂性麸质不耐受
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本文引用的文献

1
Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease.乳糜泻。II. 小麦中存在对乳糜泻患者有有害作用的一种因子。
Acta Paediatr (Stockh). 1953 Jan;42(1):34-42. doi: 10.1111/j.1651-2227.1953.tb05563.x.
2
Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients.从乳糜泻患者小肠黏膜中分离出的麦醇溶蛋白特异性、HLA - DQ（α1*0501，β1*0201）限制性T细胞。
J Exp Med. 1993 Jul 1;178(1):187-96. doi: 10.1084/jem.178.1.187.
3
HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease.西班牙乳糜泻儿童的HLA - DR表型：它们对理解该疾病遗传学的贡献。
Gut. 1983 Jun;24(6):532-7. doi: 10.1136/gut.24.6.532.
4
Influence of genetic factors on the serum levels of antigliadin antibodies in celiac disease.遗传因素对乳糜泻患者血清抗麦醇溶蛋白抗体水平的影响。
J Pediatr Gastroenterol Nutr. 1984 Jun;3(3):373-7. doi: 10.1097/00005176-198406000-00012.
5
Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease.人类小肠中的淋巴细胞亚群。正常黏膜及成人乳糜泻患者黏膜中的研究结果。
Clin Exp Immunol. 1983 Apr;52(1):219-28.
6
Evidence that celiac disease is primarily associated with a DC locus allelic specificity.乳糜泻主要与一个DC基因座等位基因特异性相关的证据。
Clin Immunol Immunopathol. 1983 Sep;28(3):395-404. doi: 10.1016/0090-1229(83)90106-x.
7
Letter: Coeliac disease and HL-A8.
Lancet. 1973 Oct 20;2(7834):908-9. doi: 10.1016/s0140-6736(73)92034-5.
8
Histocompatibility antigens associated with adult coeliac disease.与成人乳糜泻相关的组织相容性抗原。
Lancet. 1972 Jul 22;2(7769):162-4. doi: 10.1016/s0140-6736(72)91330-x.
9
HLA-DR antigens and phenotypes in Dutch coeliac children and their families.荷兰乳糜泻儿童及其家庭成员的HLA - DR抗原和表型
Clin Genet. 1985 Jan;27(1):45-50. doi: 10.1111/j.1399-0004.1985.tb00182.x.
10
A study of HLA class II antigens in an Italian paediatric population with coeliac disease.一项针对意大利患有乳糜泻的儿科人群的人类白细胞抗原II类抗原研究。
Dis Markers. 1988 Mar;6(1):23-8.

乳糜泻与暂时性麸质不耐受之间HLA - DR表型的遗传差异。

Genetic difference in HLA-DR phenotypes between coeliac disease and transitory gluten intolerance.

作者信息

Meuli R, Pichler W J, Gaze H, Lentze M J

机构信息

Department of Gastroenterology, University Children's Hospital, Berne, Switzerland.

出版信息

Arch Dis Child. 1995 Jan;72(1):29-32. doi: 10.1136/adc.72.1.29.

DOI:10.1136/adc.72.1.29
PMID:7717732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1510961/
Abstract

Genetic differences in HLA phenotypes were studied in coeliac disease to investigate why some patients do not react with mucosal damage after gluten challenge. Forty five children with coeliac disease and 16 with transitory gluten intolerance were typed; 76 subjects served as controls. HLA phenotypes in children with coeliac disease had significantly higher proportions of DR3/X and DR5/7 than controls (48.8% v 11.8% and 26.7% v 5.3%). Children with transitory gluten intolerance had lower DR3/X (43.8%) than children with coeliac disease and there were no DR5/7 phenotypes. Further analysis of similarly well defined cases might show whether genetic differences in the DR3/X and DR5/7 phenotypes can serve as a marker for the permanence of gluten intolerance.

摘要

为了研究为什么一些乳糜泻患者在麸质激发试验后没有出现黏膜损伤，对乳糜泻患者的人类白细胞抗原（HLA）表型的遗传差异进行了研究。对45例乳糜泻儿童和16例暂时性麸质不耐受儿童进行了分型；76名受试者作为对照。乳糜泻儿童的HLA表型中DR3/X和DR5/7的比例显著高于对照组（分别为48.8%对11.8%和26.7%对5.3%）。暂时性麸质不耐受儿童的DR3/X比例（43.8%）低于乳糜泻儿童，且不存在DR5/7表型。对定义相似的病例进行进一步分析可能会表明，DR3/X和DR5/7表型的遗传差异是否可作为麸质不耐受持久性的标志物。