乳糜泻与暂时性麸质不耐受之间HLA - DR表型的遗传差异。
Genetic difference in HLA-DR phenotypes between coeliac disease and transitory gluten intolerance.
作者信息
Meuli R, Pichler W J, Gaze H, Lentze M J
机构信息
Department of Gastroenterology, University Children's Hospital, Berne, Switzerland.
出版信息
Arch Dis Child. 1995 Jan;72(1):29-32. doi: 10.1136/adc.72.1.29.
Genetic differences in HLA phenotypes were studied in coeliac disease to investigate why some patients do not react with mucosal damage after gluten challenge. Forty five children with coeliac disease and 16 with transitory gluten intolerance were typed; 76 subjects served as controls. HLA phenotypes in children with coeliac disease had significantly higher proportions of DR3/X and DR5/7 than controls (48.8% v 11.8% and 26.7% v 5.3%). Children with transitory gluten intolerance had lower DR3/X (43.8%) than children with coeliac disease and there were no DR5/7 phenotypes. Further analysis of similarly well defined cases might show whether genetic differences in the DR3/X and DR5/7 phenotypes can serve as a marker for the permanence of gluten intolerance.
为了研究为什么一些乳糜泻患者在麸质激发试验后没有出现黏膜损伤，对乳糜泻患者的人类白细胞抗原（HLA）表型的遗传差异进行了研究。对45例乳糜泻儿童和16例暂时性麸质不耐受儿童进行了分型；76名受试者作为对照。乳糜泻儿童的HLA表型中DR3/X和DR5/7的比例显著高于对照组（分别为48.8%对11.8%和26.7%对5.3%）。暂时性麸质不耐受儿童的DR3/X比例（43.8%）低于乳糜泻儿童，且不存在DR5/7表型。对定义相似的病例进行进一步分析可能会表明，DR3/X和DR5/7表型的遗传差异是否可作为麸质不耐受持久性的标志物。
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