Department of Pathology and All India Institute of Medical Sciences, New Delhi, India.
Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.
Adv Wound Care (New Rochelle). 2021 May;10(5):257-269. doi: 10.1089/wound.2019.1085. Epub 2020 Aug 10.
Wound dressing based on naturally derived polymer provides a useful platform for treatment of skin injuries. Owing to the high mechanical strength and tunable structural and physicochemical properties of human elastin-like polypeptides (ELPs), they may be used as excellent materials for fabricating biocompatible scaffolds and other products for wound management. Designing recombinant ELPs mimicking natural elastin to fabricate synthetic polymers suitable for human health care has generated significant interest. ELP-based cell-adhesive biopolymers have been used as an alternative for successful sutureless wound closure due to the physicochemical characteristics of the extracellular matrix. Different systems of ELPs are being developed in the form of scaffolds, films, hydrogels, photo-linkable sheets, and composites linked with various types of growth factors for wound healing application. However, optimizing the quality and safety attributes for specific application needs designing of recombinant ELPs with structural and functional modifications as needed for the intervention. Chronic wounds are difficult to treat as the wound repair process is interrupted by conditions such as excessive inflammation, impaired extracellular matrix formation, and persistent infections. Conventional therapies such as skin substitutes or autologous skin grafts, in many cases, are unable to reestablish tissue homeostasis and proper healing. The development of innovative materials could induce a better regenerative healing response. In this study, we are reviewing different types of elastin-based materials for wound care application and their future prospects in regenerative medicine.
基于天然聚合物的创面敷料为皮肤损伤治疗提供了一个有用的平台。由于人弹性蛋白样多肽（ELP）具有较高的机械强度和可调节的结构和物理化学性质，它们可用作制造生物相容性支架和其他伤口管理产品的优异材料。设计模拟天然弹性蛋白的重组 ELP 以制造适合人类保健的合成聚合物引起了人们的极大兴趣。基于 ELP 的细胞黏附性生物聚合物已被用作成功无缝合伤口闭合的替代物，这是由于细胞外基质的物理化学特性。正在以支架、薄膜、水凝胶、光可交联片和复合材料的形式开发不同的 ELP 系统，并与各种类型的生长因子结合，用于伤口愈合应用。然而，为了优化特定应用的质量和安全属性，需要根据干预的需要对重组 ELP 进行结构和功能修饰的设计。慢性伤口难以治疗，因为伤口修复过程会因过度炎症、细胞外基质形成受损和持续感染等情况而中断。在许多情况下，传统疗法（如皮肤替代物或自体皮片移植）都无法重新建立组织内稳态和适当的愈合。创新材料的开发可以诱导更好的再生愈合反应。在本研究中，我们综述了用于伤口护理应用的不同类型的基于弹性蛋白的材料及其在再生医学中的未来前景。
