Laboratory 212, Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine Jammu, Canal Road, Jammu, Jammu and Kashmir, 180001, India.
Chemistry. 2021 Jan 18;27(4):1165-1218. doi: 10.1002/chem.202002154. Epub 2020 Nov 3.
Heteroarene-tethered functionalized alkynes are multipotent synthons in organic chemistry. This detailed Review described herein offers a thorough discussion of the metamorphosis of heteroarene-tethered functionalized alkynes, an area which has earned much attention over the past decade in the straightforward synthesis of architecturally complex heterocyclic scaffolds in atom and step economic manner. Depending upon the variety of functionalized alkynes, this Review is divided into multiple sections. Amongst the vast array of synthetic transformations covered, dearomatizing spirocyclizations and cascade spirocyclization/rearrangement are of great interest. Synthetic transformations involving the heteroarene-tethered functionalized alkynes with scope, challenges, limitations, mechanism, their application in the total synthesis of natural products and future perceptions are surveyed.
杂芳烃键联功能化炔烃是有机化学中的多用途合成子。本文详细综述了杂芳烃键联功能化炔烃的转化，在过去十年中，该领域在原子经济性和步骤经济性的方式直合成结构复杂的杂环骨架方面受到了广泛关注。根据功能化炔烃的种类，本文综述分为多个部分。在涵盖的大量合成转化中，去芳构化螺环化和级联螺环化/重排非常有趣。综述了杂芳烃键联功能化炔烃的合成转化，包括范围、挑战、限制、机理、在天然产物全合成中的应用以及未来展望。
