Department of Chemistry, University of Delhi, North Campus, Delhi 110007, India.
Department of Chemistry, Umm Al-Qura University, Makkah, Saudi Arabia.
Org Biomol Chem. 2020 May 27;18(20):3797-3817. doi: 10.1039/d0ob00325e.
Alkynes are a very important class of compounds and used as precursors for the assembly of a variety of carbocycles and heterocycles. Alkynes are classified into two classes: terminal alkynes and internal alkynes. Terminal alkynes were used as one of the precursors for the synthesis of internal alkynes. Besides, various elimination reactions were conducted to obtain alkynes. Various applications of alkynes are known but no compiled review is reported so far regarding their synthesis. Therefore, we have compiled the literature available for the synthesis of various functionalized alkynes from non-alkyne sources in this review. We have not discussed the synthesis of internal alkynes from terminal alkynes. Based on the available literature, the synthesis of alkynes can be classified into three major types of reactions: (a) synthesis of alkynes through α,β-elimination, (b) synthesis of alkynes through carbene rearrangement and (c) synthesis of alkynes via miscellaneous approaches. In this review, we have focused on the different methods available for these transformations including their scope, limitations and recent developments. We have also discussed the mechanism involved during the reaction.
炔烃是一类非常重要的化合物，可用作各种碳环和杂环化合物的组装前体。炔烃分为两类：末端炔烃和内部炔烃。末端炔烃可用作合成内部炔烃的前体之一。此外，还进行了各种消除反应来获得炔烃。炔烃的各种应用是已知的，但迄今为止尚未有关于其合成的综合评论。因此，我们在这篇综述中汇集了可用于从非炔烃源合成各种官能化炔烃的文献。我们没有讨论从末端炔烃合成内部炔烃。根据现有文献，炔烃的合成可分为三大类反应：(a) 通过α，β-消除合成炔烃，(b) 通过卡宾重排合成炔烃，(c) 通过杂项方法合成炔烃。在这篇综述中，我们重点介绍了这些转化的不同方法，包括它们的范围、限制和最新进展。我们还讨论了反应过程中涉及的机制。
