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表皮生长因子和蛋白激酶C激活剂对单个VL30元件的独立转录调控。

Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C.

作者信息

Rodland K D, Muldoon L L, Dinh T H, Magun B E

机构信息

Department of Cell Biology and Anatomy, Oregon Health Sciences University, Portland 97201.

出版信息

Mol Cell Biol. 1988 May;8(5):2247-50. doi: 10.1128/mcb.8.5.2247-2250.1988.

DOI:10.1128/mcb.8.5.2247-2250.1988
PMID:3260332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363411/
Abstract

A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation. Following TPA-induced depletion of protein kinase C activity, EGF stimulation of VL30 transcription and accumulation was unaffected while TPA effects were inhibited, implying that EGF and TPA act by separable pathways.

摘要

RVL-3细胞系中存在的单个VL30元件在受到表皮生长因子（EGF）以及蛋白激酶C（PKC）激活剂12-O-十四烷酰佛波醇-13-乙酸酯（TPA）和sn-1,2-二辛酰甘油刺激后5分钟内被转录诱导。TPA诱导蛋白激酶C活性耗竭后，EGF对VL30转录和积累的刺激不受影响，而TPA的作用受到抑制，这表明EGF和TPA通过不同的途径发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a34/363411/46d1be6f3492/molcellb00065-0399-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a34/363411/5820718105e6/molcellb00065-0398-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a34/363411/4b6b5bea5eff/molcellb00065-0398-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a34/363411/9928433f1633/molcellb00065-0399-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a34/363411/46d1be6f3492/molcellb00065-0399-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a34/363411/5820718105e6/molcellb00065-0398-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a34/363411/4b6b5bea5eff/molcellb00065-0398-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a34/363411/9928433f1633/molcellb00065-0399-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a34/363411/46d1be6f3492/molcellb00065-0399-b.jpg

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引用本文的文献

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本文引用的文献

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Anal Biochem. 1982 Sep 15;125(2):339-51. doi: 10.1016/0003-2697(82)90015-x.
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Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.pS2基因转录的激活是人类乳腺癌细胞系MCF-7对雌激素的主要反应。
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Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein.
NICER元件：一类神经生长因子诱导的可抑制环磷酸腺苷的逆转录病毒样元件。
Proc Natl Acad Sci U S A. 1990 May;87(10):3778-82. doi: 10.1073/pnas.87.10.3778.
4
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Identification of a novel enhancer element mediating calcium-dependent induction of gene expression in response to either epidermal growth factor or activation of protein kinase C.鉴定一种新型增强子元件，其介导在表皮生长因子或蛋白激酶C激活后基因表达的钙依赖性诱导。
Mol Cell Biol. 1992 Jun;12(6):2793-803. doi: 10.1128/mcb.12.6.2793-2803.1992.
血小板衍生生长因子诱导c-fos基因和蛋白的快速但短暂的表达。
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Mol Cell Biol. 1983 Dec;3(12):2221-31. doi: 10.1128/mcb.3.12.2221-2231.1983.
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Polyadenylylated RNA complementary to a mouse retrovirus-like multigene family is rapidly and specifically induced by epidermal growth factor stimulation of quiescent cells.与小鼠逆转录病毒样多基因家族互补的聚腺苷酸化RNA在静止细胞受到表皮生长因子刺激后被快速且特异性地诱导产生。
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