表皮生长因子和蛋白激酶C激活剂对单个VL30元件的独立转录调控。
Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C.
作者信息
Rodland K D, Muldoon L L, Dinh T H, Magun B E
机构信息
Department of Cell Biology and Anatomy, Oregon Health Sciences University, Portland 97201.
出版信息
Mol Cell Biol. 1988 May;8(5):2247-50. doi: 10.1128/mcb.8.5.2247-2250.1988.
A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation. Following TPA-induced depletion of protein kinase C activity, EGF stimulation of VL30 transcription and accumulation was unaffected while TPA effects were inhibited, implying that EGF and TPA act by separable pathways.
RVL-3细胞系中存在的单个VL30元件在受到表皮生长因子（EGF）以及蛋白激酶C（PKC）激活剂12-O-十四烷酰佛波醇-13-乙酸酯（TPA）和sn-1,2-二辛酰甘油刺激后5分钟内被转录诱导。TPA诱导蛋白激酶C活性耗竭后，EGF对VL30转录和积累的刺激不受影响，而TPA的作用受到抑制，这表明EGF和TPA通过不同的途径发挥作用。
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