Fietta A, Bersani C, De Rose V, Grassi F A, Mangiarotti P, Uccelli M, Grassi C
Chair of Chemotherapy, Institute of Respiratory Diseases, Pavia, Italy.
Respiration. 1988;53(1):37-43. doi: 10.1159/000195394.
Seventy-six chronic bronchitis patients were studied in order to determine the possible presence of disorders in their systemic defense mechanisms. No significant difference in lymphocyte subsets, in serum immunoglobulin and complement component (C3 and C4) levels was found in chronic bronchitis patients compared to normal adult controls. Skin tests for delayed hypersensitivity revealed a high frequency (39%) of hypoergic patients (with 1-2 positive reactions) in comparison to normal subjects. Altered values of many functional properties of both neutrophils and monocytes were demonstrated. The percentage of patients with intermediate (between 1 and 2 SD below the mean of controls) and defective (lower than 1.96 SD) values of chemotaxis, phagocytosis index and Candida killing was about 50%. Phagocytosis frequency and nitroblue tetrazolium reduction frequency were less frequently impaired.
为了确定76例慢性支气管炎患者的全身防御机制是否可能存在紊乱，对他们进行了研究。与正常成人对照组相比，慢性支气管炎患者的淋巴细胞亚群、血清免疫球蛋白和补体成分（C3和C4）水平没有显著差异。迟发型超敏反应皮肤试验显示，与正常受试者相比，低反应性患者（有1 - 2个阳性反应）的频率较高（39%）。研究还证实了中性粒细胞和单核细胞的许多功能特性值发生了改变。趋化性、吞噬指数和念珠菌杀伤能力处于中等水平（低于对照组平均值1至2个标准差之间）和存在缺陷（低于1.96个标准差）的患者比例约为50%。吞噬频率和硝基蓝四氮唑还原频率受损的情况较少见。
