Fietta A, Merlini C, De Bernardi P M, Gandola L, Piccioni P D, Grassi C
Chair of Chemotherapy, University of Pavia, Italy.
Aging (Milano). 1993 Oct;5(5):357-61. doi: 10.1007/BF03324187.
We investigated the effects of aging on some functional activities (chemotaxis, phagocytosis, nitroblue tetrazolium reduction and candidacidal activity) of peripheral polymorphonuclear and mononuclear phagocytes in 96 healthy subjects and 89 patients with chronic bronchitis, aged 40 to 100 years. The subjects were divided according to age into younger (40-65 years) and older (66-100 years) individuals. No subject was taking any drug known to affect phagocytic functions. A few abnormalities in PMN and monocyte functions were observed in aged healthy subjects, in comparison to the younger ones; in fact, only the chemotactic response to complement-derived chemotactic factors was significantly impaired in elderly healthy individuals. On the contrary, multiple alterations of phagocyte activities, i.e., chemotaxis, phagocytosis, and candidacidal activity were observed in aged subjects with chronic bronchitis, compared to healthy adults. However, the results obtained in older and younger patients with chronic bronchitis were superimposable. The present data suggest that the decline in functional activities of phagocytes in the aged could depend on the effect of the underlying chronic bronchitis on the cellular components of the non-specific host defense system, rather than a direct effect of the aging process.
我们研究了年龄对96名健康受试者和89名年龄在40至100岁之间的慢性支气管炎患者外周多形核和单核吞噬细胞的某些功能活动（趋化性、吞噬作用、硝基蓝四氮唑还原和杀念珠菌活性）的影响。根据年龄将受试者分为较年轻（40 - 65岁）和较年长（66 - 100岁）个体。没有受试者正在服用任何已知会影响吞噬功能的药物。与较年轻的健康受试者相比，在老年健康受试者中观察到多形核白细胞和单核细胞功能有一些异常；事实上，仅老年健康个体对补体衍生趋化因子的趋化反应明显受损。相反，与健康成年人相比，在患有慢性支气管炎的老年受试者中观察到吞噬细胞活动的多种改变，即趋化性、吞噬作用和杀念珠菌活性。然而，老年和年轻慢性支气管炎患者的结果是重叠的。目前的数据表明，老年人吞噬细胞功能活动的下降可能取决于潜在的慢性支气管炎对非特异性宿主防御系统细胞成分的影响，而不是衰老过程的直接影响。
