Laharrague P, Corberand J, Fillola G, Leophonte P, Gleizes B, Fontanilles A M, Gyrard E
J Clin Lab Immunol. 1985 May;17(1):21-4.
Polymorphonuclear (PMN) functions were assessed in 55 patients with asthma or bronchial bacterial infection to evaluate the systemic phagocyte capability of patients with bronchopulmonary diseases. Random migration, nitroblue tetrazolium dye reduction, and Candida killing activity were markedly decreased in the 2 types of patients studied. PMN dysfunction was more pronounced in the most affected and heavily treated patients. Considering both the rare occurrence of congenital polymorphonuclear defects and the age of the patients studied we concluded that the PMN abnormalities observed were secondary to the onset of respiratory disease. This impairment of circulating phagocytes may contribute to the rise of a systemic susceptibility to infection able to aggravate the underlying bronchopulmonary disease.
对55例哮喘或支气管细菌感染患者的多形核白细胞（PMN）功能进行评估，以评价支气管肺部疾病患者的全身吞噬细胞能力。在所研究的两类患者中，随机迁移、硝基蓝四氮唑染料还原及白色念珠菌杀伤活性均显著降低。在病情最严重且接受大量治疗的患者中，PMN功能障碍更为明显。鉴于先天性多形核白细胞缺陷罕见且所研究患者的年龄情况，我们得出结论，观察到的PMN异常是呼吸系统疾病发作的继发表现。循环吞噬细胞的这种损伤可能导致全身感染易感性增加，从而加重潜在的支气管肺部疾病。
