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基于生物信息学和药物设计的 SARS-CoV-2 虚拟生化实验室。

SARS-CoV-2 virtual biochemistry labs on bioinformatics and drug design.

机构信息

Franklin and Marshall College Department of Chemistry, Lancaster, Pennsylvania, USA.

Wabash College Department of Chemistry, Crawfordsville, Indiana, USA.

出版信息

Biochem Mol Biol Educ. 2021 Jan;49(1):26-28. doi: 10.1002/bmb.21480. Epub 2020 Dec 10.

Abstract

Colleges and universities are learning to provide relevant virtual lab experiences for students due to the COVID-19 pandemic. Even schools attempting in-person instruction often need to utilize virtual experiences for students absent due to quarantine or illness. Much of biochemistry is amenable to molecular visualization and/or computational study; however, many faculty face learning how to utilize new computational and molecular visualization software. We present a set of virtual lab exercises with detailed instructions to engage students in the discovery of novel antiviral compounds against the SARS-CoV-2 main protease.

摘要

由于 COVID-19 大流行,高校正在学习为学生提供相关的虚拟实验室体验。即使是采用面授教学的学校,也常常需要为因隔离或患病而缺勤的学生提供虚拟体验。生物化学的很大一部分内容适合进行分子可视化和/或计算研究;然而,许多教师需要学习如何使用新的计算和分子可视化软件。我们提供了一组带有详细说明的虚拟实验室练习,以激发学生发现针对 SARS-CoV-2 主蛋白酶的新型抗病毒化合物。

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