Glicklich D, Haskell L, Senitzer D, Weiss R A
Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467.
Am J Kidney Dis. 1988 Jul;12(1):26-30. doi: 10.1016/s0272-6386(88)80067-2.
HLA-A, B, and DR antigen frequencies were studied in a group of 57 patients to determine possible inborn susceptibility to idiopathic focal segmental glomerulosclerosis (FSGS). There were 34 white patients and 23 black patients, most of whom had nephrotic syndrome and later developed renal failure. HLA-DR4 was significantly increased in both patient groups when compared with their respective control groups. This association has not been previously reported. Of note, the association with DR4 was most striking in patients with adult onset disease (in blacks, relative risk equals 5.2; in whites, relative risk equals 5.8). No other antigen was increased in both patient groups but HLA-A28 was increased in blacks. These data support the notion of genetic predisposition to focal segmental glomerulosclerosis in two different ethnic groups.
对一组57例患者的人类白细胞抗原A、B和DR抗原频率进行了研究，以确定特发性局灶节段性肾小球硬化症（FSGS）可能的先天性易感性。其中有34例白人患者和23例黑人患者，他们大多数患有肾病综合征，随后发展为肾衰竭。与各自的对照组相比，两个患者组中的HLA-DR4均显著增加。这种关联此前尚未见报道。值得注意的是，DR4与成人发病患者的关联最为显著（黑人中相对风险等于5.2；白人中相对风险等于5.8）。两个患者组中均未发现其他抗原增加，但黑人中的HLA-A28增加。这些数据支持了两个不同种族对局灶节段性肾小球硬化症存在遗传易感性的观点。
