Trainin E B, Gomez-Leon G
Int J Pediatr Nephrol. 1983 Mar;4(1):59-60.
Two HLA identical siblings developed focal glomerulosclerosis at about 15 years of age. To our knowledge, this is a unique case of the familial nephrotic syndrome because this is both the latest onset ever reported and the first description of HLA identity. We suggest that the pathogenesis of renal disease in these siblings involved an interaction of a shared genetic susceptibility and a common environment.
两名 HLA 相同的同胞在大约 15 岁时患上局灶节段性肾小球硬化症。据我们所知，这是家族性肾病综合征的一个独特病例，因为这是迄今报道的发病年龄最晚的病例，也是对 HLA 相同情况的首次描述。我们认为，这些同胞中肾脏疾病的发病机制涉及共同遗传易感性和共同环境的相互作用。
