HLA identity in siblings with focal glomerulosclerosis.

Two HLA identical siblings developed focal glomerulosclerosis at about 15 years of age. To our knowledge, this is a unique case of the familial nephrotic syndrome because this is both the latest onset ever reported and the first description of HLA identity. We suggest that the pathogenesis of renal disease in these siblings involved an interaction of a shared genetic susceptibility and a common environment.