Brown M D, Ellis C N, Billings J, Cooper K D, Baadsgaard O, Headington J T, Voorhees J J
Department of Dermatology, University of Michigan, Ann Arbor 48109-0314.
Arch Dermatol. 1988 Jul;124(7):1097-100.
Cyclosporine, a potent immunosuppressive agent, has been successfully used in the treatment of several dermatologic conditions including psoriasis. However, the drug does have an array of toxic side effects that need to be carefully considered when determining the risk-benefit ratio for the treatment of skin disease. We present another potential adverse effect of cyclosporine, namely, a benign lymphocytic infiltrate. This eruption developed in a patient with psoriasis after only ten days of cyclosporine therapy. The exact mechanism by which cyclosporine induced the lymphocytic infiltrate is unknown, but it is postulated that cyclosporine caused an imbalance of T-cell regulatory systems, thus resulting in an expanded T-cell subpopulation and the clinical manifestation of erythematous papules and nodules.
环孢素是一种强效免疫抑制剂，已成功用于治疗包括银屑病在内的多种皮肤病。然而，在确定治疗皮肤病的风险效益比时，该药物确实存在一系列毒性副作用，需要仔细考虑。我们报告环孢素的另一种潜在不良反应，即良性淋巴细胞浸润。该皮疹出现在一名银屑病患者身上，仅在接受环孢素治疗十天后就出现了。环孢素诱导淋巴细胞浸润的确切机制尚不清楚，但据推测，环孢素导致了T细胞调节系统失衡，从而导致T细胞亚群扩大，并出现红斑丘疹和结节的临床表现。
