[环孢素在皮肤科的应用]
[Cyclosporin in dermatology].
作者信息
Salomon D, Halioua B
机构信息
Clinique de dermatologie, Hôpital cantonal universitaire, Genève.
出版信息
Schweiz Rundsch Med Prax. 1990 Oct 16;79(42):1258-61.
Cyclosporin is a potent immunosuppressive agent with a selective and reversible inhibitory effect on helper T lymphocytes functions mainly interleukin-2 production. Cyclosporin has no myelotoxic, mutagenic or teratogenic effect. The drug is effective in preventing organ rejection, as well as in various auto-immune and inflammatory diseases. In dermatology the drug is extremely effective in psoriasis. Low doses (less than 5 mg/kg per day) have to be used to decrease the risk of nephrotoxicity and hypertension.
环孢素是一种强效免疫抑制剂，对辅助性T淋巴细胞功能具有选择性和可逆性抑制作用，主要抑制白细胞介素-2的产生。环孢素没有骨髓毒性、致突变性或致畸性。该药物在预防器官排斥以及各种自身免疫性和炎性疾病方面有效。在皮肤科，该药物对银屑病极为有效。必须使用低剂量（每天小于5毫克/千克）以降低肾毒性和高血压的风险。
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