Biren C A, Barr R J
Arch Dermatol. 1986 Sep;122(9):1028-32.
It is evident that cyclosporine A is a potent immunosuppressive agent and may become immensely valuable in the treatment of cutaneous disease. The extent of its application and efficacy is speculative, as neither the pathogenesis of many of the diseases, nor the mechanism of action of cyclosporine is fully understood. Well-designed clinical and laboratory studies are necessary to delineate its therapeutic value in a particular disorder. It must be emphasized that the systemic use of the drug is associated with several serious side effects, including nephrotoxicity and lymphoproliferative disease. Local topical application may reduce these concerns, and make treatment of benign diseases a possibility. Therefore, until these well-designed prospective studies are performed, cyclosporine's use should be limited and closely monitored.
显然，环孢素A是一种强效免疫抑制剂，在皮肤病治疗中可能具有巨大价值。其应用范围和疗效尚属推测，因为许多疾病的发病机制以及环孢素的作用机制均未完全明了。需要精心设计的临床和实验室研究来确定其在特定疾病中的治疗价值。必须强调的是，该药物的全身应用会带来一些严重副作用，包括肾毒性和淋巴增殖性疾病。局部外用可能会减少这些担忧，并使良性疾病的治疗成为可能。因此，在进行这些精心设计的前瞻性研究之前，环孢素的使用应受到限制并密切监测。
