Division of Cellular Immunology, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Int J Mol Sci. 2020 Jun 27;21(13):4573. doi: 10.3390/ijms21134573.
Some intracellular pathogens are able to avoid the defense mechanisms contributing to host epigenetic modifications. These changes trigger alterations tothe chromatin structure and on the transcriptional level of genes involved in the pathogenesis of many bacterial diseases. In this way, pathogens manipulate the host cell for their own survival. The better understanding of epigenetic consequences in bacterial infection may open the door for designing new vaccine approaches and therapeutic implications. This article characterizes selected intracellular bacterial pathogens, including spp., spp., spp., spp., spp., spp. and spp., which can modulate and reprogram of defense genes in host innate immune cells.
一些细胞内病原体能够逃避有助于宿主表观遗传修饰的防御机制。这些变化引发了参与许多细菌疾病发病机制的基因的染色质结构和转录水平的改变。通过这种方式，病原体为了自身的生存而操纵宿主细胞。更好地了解细菌感染中的表观遗传后果可能为设计新的疫苗方法和治疗意义开辟道路。本文描述了几种能够调节和重编程宿主固有免疫细胞中防御基因的选定细胞内细菌病原体，包括 spp.、 spp.、 spp.、 spp.、 spp.、 spp. 和 spp.。
