Simmons Pilar, McElroy Taylor, Allen Antiño R
Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Materials (Basel). 2020 Jun 27;13(13):2891. doi: 10.3390/ma13132891.
Artificial extracellular matrices (aECMs) are an extension of biomaterials that were developed as model environments for tissue cells that mimic the native in vivo target tissues' structure. This bibliometric analysis evaluated the research productivity regarding aECM based on tissue engineering technology. The Web of Science citation index was examined for articles published from 1990 through 2019 using three distinct aECM‑related topic sets. Data were also visualized using network analyses (VOSviewer). Terms related to scaffolds, collagen, hydrogels, and differentiation were reoccurring in the aECM‑related literature over time. Publications with terms related to a clinical direction (wound healing, stem cells, artificial skin, and bone regeneration) have steadily increased, as have the number of countries and institutions involved in the artificial extracellular matrix. As progress with 3D scaffolds continues to advance, it will become the most promising technology to provide a therapeutic option to repair or replace damaged tissue.
人工细胞外基质（aECM）是生物材料的一种延伸，它被开发为组织细胞的模型环境，以模拟天然体内靶组织的结构。这项文献计量分析基于组织工程技术评估了关于aECM的研究生产力。使用三个不同的与aECM相关的主题集，对1990年至2019年发表在科学网引文索引中的文章进行了审查。数据还使用网络分析（VOSviewer）进行了可视化处理。随着时间的推移，与支架、胶原蛋白、水凝胶和分化相关的术语在与aECM相关的文献中反复出现。与临床方向（伤口愈合、干细胞、人工皮肤和骨再生）相关术语的出版物稳步增加，参与人工细胞外基质研究的国家和机构数量也在增加。随着3D支架技术的不断进步，它将成为提供修复或替换受损组织治疗选择的最有前途的技术。
