基于定量磁化率映射的短回波时间幅度图像在黑质中类似于神经黑色素敏感 MRI 图像。
Short-echo-time magnitude image derived from quantitative susceptibility mapping could resemble neuromelanin-sensitive MRI image in substantia nigra.
机构信息
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, 200040, China.
出版信息
BMC Neurol. 2020 Jun 30;20(1):262. doi: 10.1186/s12883-020-01828-8.
BACKGROUND
In this study, we explored whether the proposed short-echo-time magnitude (setMag) image derived from quantitative susceptibility mapping (QSM) could resemble NM-MRI image in substantia nigra (SN), by quantitatively comparing the spatial similarity and diagnosis performances for Parkinson's disease (PD).
METHODS
QSM and NM-MRI were performed in 18 PD patients and 15 healthy controls (HCs). The setMag images were calculated using the short-echo-time magnitude images. Bilateral hyperintensity areas of SN (SN) were manually segmented on setMag and NM-MRI images by two raters in a blinded manner. The inter-rater reliability was evaluated by the intraclass correlation coefficients (ICC) and the Dice similarity coefficient (DSC). Then the inter-modality (i.e. setMag and NM-MRI) spatial similarity was quantitatively assessed using DSC and volume of the consensual voxels identified by both of two raters. The performances of mean SN volume for PD diagnosis on setMag and NM-MRI images were evaluated using receiver operating characteristic (ROC) analysis.
RESULTS
The SN segmented by two raters showed substantial to excellent inter-rater reliability for both setMag and NM-MRI images. The DSCs of SN between setMag and NM-MRI images showed substantial to excellent voxel-wise overlap in HCs (0.80 ~ 0.83) and PD (0.73 ~ 0.76), and no significant difference was found between the SN volumes of setMag and NM-MRI images in either HCs or PD (p > 0.05). The mean SN volume was significantly decreased in PD patients in comparison with HCs on both setMag images (77.61 mm vs 95.99 mm, p < 0.0001) and NM-MRI images (79.06 mm vs 96.00 mm, p < 0.0001). Areas under the curve (AUCs) of mean SN volume for PD diagnosis were 0.904 on setMag and 0.906 on NM-MRI images. No significant difference was found between the two curves (p = 0.96).
CONCLUSIONS
SN on setMag derived from QSM demonstrated substantial spatial overlap with that on NM-MRI and provided comparable PD diagnostic performance, providing a new QSM-based multi-contrast imaging strategy for future PD studies.
背景
在这项研究中，我们通过定量比较帕金森病（PD）的空间相似性和诊断性能，探索了从定量磁化率映射（QSM）中提取的短回波时间幅度（setMag）图像是否可以类似于黑质（SN）的 NM-MRI 图像。
方法
在 18 名 PD 患者和 15 名健康对照者（HCs）中进行了 QSM 和 NM-MRI 检查。使用短回波时间幅度图像计算 setMag 图像。由两名审阅者以盲法方式手动在 setMag 和 NM-MRI 图像上对 SN 的双侧高信号区（SN）进行分割。通过组内相关系数（ICC）和 Dice 相似系数（DSC）评估观察者间的可靠性。然后，使用 DSC 和由两名审阅者共同识别的一致体素的体积来定量评估两种模态（即 setMag 和 NM-MRI）之间的空间相似性。使用受试者工作特征（ROC）分析评估 setMag 和 NM-MRI 图像上 PD 诊断的平均 SN 体积的性能。
结果
两名审阅者对 setMag 和 NM-MRI 图像的 SN 分割均显示出较大到极好的观察者间可靠性。HC（0.800.83）和 PD（0.730.76）的 SN 之间的 DSCs 表现出明显的体素重叠，在 HCs 或 PD 中均未发现 setMag 和 NM-MRI 图像的 SN 体积之间存在显著差异（p>0.05）。与 HCs 相比，PD 患者的平均 SN 体积在 setMag 图像（77.61mm 比 95.99mm，p<0.0001）和 NM-MRI 图像（79.06mm 比 96.00mm，p<0.0001）上均显著降低。基于 setMag 的平均 SN 体积诊断 PD 的曲线下面积（AUC）分别为 0.904 和 0.906。两个曲线之间没有显著差异（p=0.96）。
结论
来自 QSM 的 setMag 上的 SN 与 NM-MRI 上的 SN 具有显著的空间重叠，提供了可比较的 PD 诊断性能，为未来的 PD 研究提供了一种新的基于 QSM 的多对比度成像策略。
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