Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Neurosci Bull. 2017 Oct;33(5):561-567. doi: 10.1007/s12264-017-0138-x. Epub 2017 May 17.
The identification of sensitive and specific biomarkers for Parkinson's disease (PD) poses an important clinical challenge. A potential biomarker for early diagnosis and disease monitoring of PD is region-specific iron. Iron accumulation in the substantia nigra pars compacta is considered a main characteristic of PD. However, questions remain, such as the relationship between nigral iron and clinical indices of PD (motor impairment or disease duration). Further, previous studies have suggested the influence of iron on other nuclei. Iron quantification using magnetic resonance imaging (MRI) allows for studies of the relationship between regional iron and clinical symptoms in vivo. Thus, in this review we discuss the following topics: the technological development of MRI in measuring brain iron, nigral iron as a potential marker for PD in both clinical and prodromal stages, other influences of regional iron on PD, and clinical translation and future perspectives.
帕金森病（PD）的敏感和特异性生物标志物的鉴定是一个重要的临床挑战。区域特异性铁是 PD 的早期诊断和疾病监测的潜在生物标志物。铁在黑质致密部的积累被认为是 PD 的一个主要特征。然而，仍存在一些问题，例如黑质铁与 PD 的临床指标（运动障碍或疾病持续时间）之间的关系。此外，先前的研究表明铁对其他核团的影响。磁共振成像（MRI）的铁定量允许研究体内区域铁与临床症状之间的关系。因此，在本综述中，我们讨论了以下主题：MRI 测量脑铁的技术发展、黑质铁作为 PD 的潜在标志物在临床和前驱期、区域铁对 PD 的其他影响，以及临床转化和未来展望。
