Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
In Vivo. 2020 Jul-Aug;34(4):1883-1892. doi: 10.21873/invivo.11984.
BACKGROUND/AIM: To evaluate the outcome of definitive salvage radiotherapy (RT) in non-small cell lung cancer (NSCLC) patients with oligo-recurrence in regional lymph nodes after surgery.
Between January 2003 and December 2016, 33 patients with NSCLC were reviewed from radiotherapy database at our hospital. All patients received photon or proton salvage RT for metastases in the regional lymph nodes.
The median follow-up from salvage RT was 35.2 (range=5.9-89.6) months. Recurrences occurred in 18 (55%) patients, and the 3-year overall and progression-free survival rates were 63.8% and 45.1%, respectively. Regional and local control improved patients' survival and these control rates were increased by use of concurrent chemotherapy (p=0.039) and proton RT (p=0.084). No grade 4 acute or late non-hematologic toxicities were observed.
Salvage RT is an effective treatment for NSCLC patients with oligo-recurrence at regional lymph nodes.
背景/目的：评估非小细胞肺癌（NSCLC）患者术后区域淋巴结寡复发时行根治性挽救性放疗（RT）的疗效。
回顾性分析 2003 年 1 月至 2016 年 12 月期间我院放疗数据库中 33 例 NSCLC 患者的资料，所有患者均因区域淋巴结转移行光子或质子挽救性 RT。
从挽救性 RT 开始随访中位数时间为 35.2（范围=5.9-89.6）个月。18 例（55%）患者出现复发，3 年总生存率和无进展生存率分别为 63.8%和 45.1%。区域控制和局部控制改善了患者的生存，同期化疗（p=0.039）和质子 RT（p=0.084）可提高这些控制率。未观察到 4 级急性或迟发性非血液学毒性。
挽救性 RT 是治疗 NSCLC 患者区域淋巴结寡复发的有效方法。
