术前 C 反应蛋白/白蛋白比值作为胆囊癌的预测因子。
Preoperative C-Reactive Protein/Albumin Ratio as a Predictive Factor for Gallbladder Carcinoma.
机构信息
Department of Surgery, National Hospital Organization, Iwakuni Clinical Center, Yamaguchi, Japan
Department of Surgery, National Hospital Organization, Iwakuni Clinical Center, Yamaguchi, Japan.
出版信息
In Vivo. 2020 Jul-Aug;34(4):1901-1908. doi: 10.21873/invivo.11986.
BACKGROUND/AIM: The C-reactive protein (CRP) to albumin ratio (CAR) is associated with outcomes in patients with sepsis. We aimed to evaluate the significance of preoperative CAR in therapeutic outcomes after gallbladder carcinoma (GBC) resection.
PATIENTS AND METHODS
Fifty-three patients who underwent surgical resection for GBC between January 2008 and September 2019 were enrolled. We retrospectively investigated the relation between preoperative CAR and overall and disease-free survival.
RESULTS
The optimal cut-off CAR was 0.07. Multivariate analysis showed that i) R1 or R2 resection (p=0.033), ii) advanced tumor stage (p=0.047), iii) CAR≥0.07 (p=0.011), and iv) postoperative complications (p=0.028) were significant independent predictors of overall survival; moreover, higher carbohydrate antigen levels (p=0.036) and R1 or R2 resection (p<0.001) were significant independent predictors of disease-free survival.
CONCLUSION
Preoperative CAR may be a significant independent predictor of long-term outcomes after GBC resection.
背景/目的：C 反应蛋白（CRP）与白蛋白比值（CAR）与脓毒症患者的预后相关。我们旨在评估术前 CAR 在胆囊癌（GBC）切除术后治疗结果中的意义。
患者与方法
2008 年 1 月至 2019 年 9 月期间，53 例接受 GBC 手术切除的患者入组。我们回顾性研究了术前 CAR 与总生存期和无病生存期之间的关系。
结果
最佳的 CAR 截断值为 0.07。多因素分析表明：i）R1 或 R2 切除术（p=0.033），ii）晚期肿瘤分期（p=0.047），iii）CAR≥0.07（p=0.011），以及 iv）术后并发症（p=0.028）是总生存期的独立显著预测因素；此外，较高的碳水化合物抗原水平（p=0.036）和 R1 或 R2 切除术（p<0.001）是无病生存期的独立显著预测因素。
结论
术前 CAR 可能是 GBC 切除术后长期预后的独立显著预测因素。
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