血清 C 反应蛋白与白蛋白比值对胰腺癌根治性切除术后患者的预测价值：一项回顾性单中心研究。
The Predictive Value of the CRP-to-Albumin Ratio for Patients With Pancreatic Cancer After Curative Resection: A Retrospective Single Center Study.
机构信息
Division of General Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
Division of General Surgery, Department of Surgery, Medical University of Graz, Graz, Austria
出版信息
In Vivo. 2019 Nov-Dec;33(6):2071-2078. doi: 10.21873/invivo.11706.
Abstract
BACKGROUND/AIM: Prognostic factors like the CRP-to-albumin ratio (CAR) represent potential predictors for survival of pancreatic cancer patients. We aimed to investigate the prognostic strength of the CAR for overall survival of patients with pancreatic cancer undergoing pancreatic resection.
PATIENTS AND METHODS
Data from a total of 202 patients with pancreatic adenocarcinoma who had undergone curative pancreatic resection were subjected to a retrospective review. Overall survival was calculated according to the Kaplan-Meier method, and multivariate Cox regression analysis was used for calculating the prognostic strength of CAR.
RESULTS
CAR was an independent prognostic factor of overall survival in univariate and multivariate Cox regression analysis. Elevated CAR was associated with a higher median value of Charlson Index, higher Union for International Cancer Control (UICC) classification and increased carcinoembryonic antigen (CEA) levels.
CONCLUSION
CAR is a useful prognostic factor for the prediction of overall survival for patients undergoing pancreatic surgery. The impact of CAR in individual risk assessment should be evaluated in further studies.
摘要
背景/目的：C 反应蛋白与白蛋白比值（CAR）等预后因素是预测胰腺癌患者生存的潜在指标。本研究旨在探讨 CAR 对接受胰腺切除术的胰腺癌患者总生存的预后价值。
患者与方法
回顾性分析了 202 例接受根治性胰腺切除术的胰腺腺癌患者的数据。根据 Kaplan-Meier 法计算总生存时间，采用多变量 Cox 回归分析计算 CAR 的预后强度。
结果
在单变量和多变量 Cox 回归分析中，CAR 是总生存的独立预后因素。CAR 升高与 Charlson 指数中位数较高、国际抗癌联盟（UICC）分期较高和癌胚抗原（CEA）水平升高相关。
结论
CAR 是预测胰腺手术后患者总生存的有用预后因素。在进一步的研究中，应评估 CAR 在个体风险评估中的作用。
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