Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University, Chieti, Italy
Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University, Chieti, Italy.
In Vivo. 2020 Jul-Aug;34(4):1981-1986. doi: 10.21873/invivo.11995.
To delineate cervical cancer gross tumor volume (GTV) on T2-magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) maps, assessing volumes and inter-observer agreement between two observers.
A radiologist and a radiation oncologist delineated GTV on T2 (T2) and ADC (ADC) sequences. Dice similarity index (DICE) and Bland-Altman analysis were used to estimated concordance.
Mean T2 and ADC volumes were 43.84±71.47 cc and 37.28±68.92 cc according to the radiologist, and 43.4±70.44 cc and 36.65±69.21 cc according to the radiation oncologist. ADC led to statistically significantly smaller volumes compared to T2. The mean DICE index was 0.86 for T2 and 0.84 for ADC The Bland-Altman plots globally showed concordance.
GTV delineation was smaller in the ADC maps compared to T2-MRI, reaching an almost perfect agreement between observers. Thanks to this acceptable variability, adding functional imaging might provide more information for tumor delineation, improving reproducibility for image-guided adaptive radiotherapy.
在 T2 磁共振成像（MRI）和表观扩散系数（ADC）图上描绘宫颈癌大体肿瘤体积（GTV），评估两位观察者之间的体积和观察者间一致性。
一名放射科医生和一名放射肿瘤学家在 T2（T2）和 ADC（ADC）序列上描绘 GTV。使用 Dice 相似性指数（DICE）和 Bland-Altman 分析来估计一致性。
根据放射科医生的测量，T2 和 ADC 的平均体积分别为 43.84±71.47cc 和 37.28±68.92cc，根据放射肿瘤学家的测量，T2 和 ADC 的平均体积分别为 43.4±70.44cc 和 36.65±69.21cc。与 T2 相比，ADC 导致的体积明显更小。T2 的平均 DICE 指数为 0.86，ADC 为 0.84。Bland-Altman 图总体上显示出一致性。
与 T2-MRI 相比，ADC 图上的 GTV 描绘更小，观察者之间达到几乎完美的一致性。由于这种可接受的变异性，添加功能成像可能为肿瘤描绘提供更多信息，提高图像引导自适应放疗的可重复性。
