Division of Breast and Endocrine Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan
Division of Breast and Endocrine Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan.
In Vivo. 2020 Jul-Aug;34(4):2033-2036. doi: 10.21873/invivo.12003.
BACKGROUND/AIM: We examined the relationship between preoperative serum albumin levels and long-term outcomes in patients with breast cancer.
We retrospectively analyzed the records of 157 patients who underwent breast cancer surgery at a single institution. We divided the patients into those with <4.0 g/dl and those with ≥4.0 g/dl preoperative serum albumin.
The overall median follow-up period was 86.7 months. Among the 157 patients, 19 (12.1%) had decreased serum albumin levels preoperatively. A significant association with preoperative albumin levels was found only for patient age; however, we were unable to determine an association between preoperative albumin levels and various clinical features. The recurrence-free survival (p=0.030) and the overall survival (p=0.001) were both significantly shorter in patients with low albumin levels.
Low serum albumin levels were associated with poor prognosis, but not with poor-prognostic factors. Therefore, low albumin levels may reflect the tumor microenvironment in breast cancer.
背景/目的：我们研究了术前血清白蛋白水平与乳腺癌患者长期预后之间的关系。
我们回顾性分析了在一家机构接受乳腺癌手术的 157 例患者的记录。我们将患者分为术前血清白蛋白 <4.0 g/dl 和 ≥4.0 g/dl 的两组。
157 例患者的总中位随访期为 86.7 个月。在 157 例患者中，术前有 19 例（12.1%）患者血清白蛋白水平降低。仅患者年龄与术前白蛋白水平有显著相关性；然而，我们无法确定术前白蛋白水平与各种临床特征之间的关联。低白蛋白组的无复发生存率（p=0.030）和总生存率（p=0.001）均显著缩短。
低血清白蛋白水平与预后不良相关，但与不良预后因素无关。因此，低白蛋白水平可能反映了乳腺癌中的肿瘤微环境。
