一项关于自身免疫性大疱性疾病患者合并症的单中心回顾性观察研究。
A Monocentric Retrospective Observational Study of Comorbidities in Patients Affected by Autoimmune Bullous Diseases.
机构信息
Unit of Dermatology, University of Padua, Padua, Italy.
Unit of Dermatology, University of Padua, Padua, Italy
出版信息
In Vivo. 2020 Jul-Aug;34(4):2113-2118. doi: 10.21873/invivo.12016.
BACKGROUND/AIM: Autoimmune bullous diseases (AIBDs) of the skin and mucosae include a heterogeneous group of chronic diseases, which could be associated with various comorbidities. The purpose of this study was to evaluate the comorbidity profiles of patients affected by AIBDs, who referred to the Dermatological Clinic of Padua from December 2015 to June 2018.
PATIENTS AND METHODS
A monocentric retrospective observational study was conducted on 157 patients with diagnosis of AIBDs. Patients' comorbidities were investigated during the periodic visits of follow-up and through the analysis of computerized medical records.
RESULTS
Among the 157 patients, 40 (25.5%) were diagnosed with PV, 15 (9.6%) with PF, and 102 (64.9%) with BP. Nine different comorbidities were observed, but only two of these were statistically significantly associated with BP: type 2 diabetes (p=0.0142) and neuropsychiatric disorders (p=0.015).
CONCLUSION
BP is statistically significantly associated with type 2 diabetes mellitus and neuropsychiatric diseases. The correlation with neuropsychiatric pathologies is interesting for the possible bidirectional role in their etiology. The association with type 2 diabetes mellitus could suggest more caution in the administration of systemic corticosteroids, especially in elderly patients.
背景/目的：皮肤黏膜自身免疫性大疱病（AIBDs）包括一组异质性的慢性疾病，可能与各种合并症相关。本研究旨在评估 2015 年 12 月至 2018 年 6 月期间至帕多瓦皮肤科诊所就诊的 AIBD 患者的合并症特征。
患者和方法
对 157 例 AIBD 患者进行了单中心回顾性观察性研究。通过定期随访期间的调查和计算机医疗记录分析来研究患者的合并症。
结果
在 157 例患者中，40 例（25.5%）被诊断为 PV，15 例（9.6%）为 PF，102 例（64.9%）为 BP。观察到 9 种不同的合并症，但只有其中两种与 BP 有统计学显著相关性：2 型糖尿病（p=0.0142）和神经精神障碍（p=0.015）。
结论
BP 与 2 型糖尿病和神经精神疾病具有统计学显著相关性。与神经精神病理的相关性对于其病因学中可能的双向作用很有趣。与 2 型糖尿病的相关性可能表明在给予全身皮质类固醇时应更加谨慎，尤其是在老年患者中。
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