Hsu Derek Y, Brieva Joaquin, Nardone Beatrice, West Dennis, Silverberg Jonathan I
Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Dermatol Online J. 2017 Dec 15;23(12):13030/qt1vk2m30m.
Pemphigus is a group of debilitating autoimmune blistering disorders associated with painful blisters of the skin and/or mucous membranes. Identification and management of the comorbiditiesof pemphigus is critically important to minimize morbidity and decrease mortality.
To identify the comorbid health conditions of pemphigus vulgaris.
This was a case-control study of 130 cases of pemphigus verified by a clinical and laboratory diagnosis and 390 age and sex-matched controls with complete follow-up at a large metropolitanquaternary care medical center.
Pemphigus vulgaris and its treatments were significantly associated with type 2 diabetes mellitus (adjusted odds ratio [95% confidence interval]: 5.68 [2.93-11.02]), hypertension (2.15 [1.25-3.71]), osteopenia (10.07 [3.72-27.25]), osteoporosis (4.19 [1.50-11.73]), cataracts (7.00 [1.81-27.07]), insomnia (15.00 [1.75-128.39]), and benign prostatic hyperplasia (6.84 [1.79-26.18]). A history of taking systemic corticosteroids was found in 76% of pemphigus vulgaris patients. There were significant statistical interactions between pemphigus vulgaris and a history of using systemic corticosteroids as predictors of diabetes mellitus type 2, hypertension, osteoporosis, and insomnia.
Safer and more effective systemic treatment options are needed for pemphigus to minimize iatrogenic complications of disease.
天疱疮是一组使人衰弱的自身免疫性水疱性疾病，伴有皮肤和/或黏膜疼痛性水疱。识别和管理天疱疮的合并症对于将发病率降至最低和降低死亡率至关重要。
确定寻常型天疱疮的合并健康状况。
这是一项病例对照研究，纳入了130例经临床和实验室诊断确诊的天疱疮患者，以及390例年龄和性别匹配的对照者，这些对照者在一家大型都市四级医疗中心接受了完整的随访。
寻常型天疱疮及其治疗与2型糖尿病（校正比值比[95%置信区间]：5.68[2.93 - 11.02]）、高血压（2.15[1.25 - 3.71]）、骨质减少（10.07[3.72 - 27.25]）、骨质疏松症（4.19[1.50 - 11.73]）、白内障（7.00[1.81 - 27.07]）、失眠（15.00[1.75 - 128.39]）和良性前列腺增生（6.84[1.79 - 26.18]）显著相关。76%的寻常型天疱疮患者有服用全身性皮质类固醇的病史。寻常型天疱疮与使用全身性皮质类固醇的病史之间存在显著的统计学交互作用，可作为2型糖尿病、高血压、骨质疏松症和失眠的预测指标。
天疱疮需要更安全、有效的全身治疗方案，以尽量减少疾病的医源性并发症。
