微卫星不稳定性相关炎症标志物及其在新辅助放化疗后直肠癌中的预后价值：一项假说生成研究。
Microsatellite Instability Correlated Inflammatory Markers and their Prognostic Value in the Rectal Cancer Following Neoadjuvant Chemoradiotherapy: A Hypothesis-generating Study.
机构信息
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
出版信息
In Vivo. 2020 Jul-Aug;34(4):2119-2126. doi: 10.21873/invivo.12017.
Abstract
BACKGROUND/AIM: This study aimed to analyze the correlation between microsatellite instability (MSI) and inflammatory markers during neoadjuvant CRT in rectal cancer and its influence on prognosis.
PATIENTS AND METHODS
A total of 549 patients with locally advanced rectal cancer underwent neoadjuvant CRT. Complete blood counts before CRT, and 4-8 weeks after CRT were used to measure neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).
RESULTS
MSI was significantly associated with elevated NLR and PLR after CRT as well as with a change in NLR and PLR during CRT. Neither inflammatory markers nor MSI significantly related to survival. However, in patients with MSI, an increase in NLR and PLR before CRT was significantly correlated with poor overall survival and disease-free survival.
CONCLUSION
There is correlation between inflammatory markers and MSI during CRT and it influences prognosis. Therefore, inflammatory markers might have a role in assessing the microenvironment related to MSI and the immunologic response in rectal cancer.
摘要
背景/目的：本研究旨在分析直肠癌新辅助 CRT 过程中微卫星不稳定性（MSI）与炎症标志物的相关性及其对预后的影响。
患者与方法
共有 549 例局部进展期直肠癌患者接受新辅助 CRT。在 CRT 前和 CRT 后 4-8 周，进行全血细胞计数以测量中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）。
结果
MSI 与 CRT 后 NLR 和 PLR 升高以及 CRT 期间 NLR 和 PLR 的变化显著相关。炎症标志物和 MSI 均与生存无显著相关性。然而，在 MSI 患者中，CRT 前 NLR 和 PLR 的增加与总生存和无病生存不良显著相关。
结论
在 CRT 过程中，炎症标志物与 MSI 之间存在相关性，并影响预后。因此，炎症标志物可能在评估与 MSI 相关的微环境和直肠癌的免疫反应方面具有一定作用。
相似文献
1
Microsatellite Instability Correlated Inflammatory Markers and their Prognostic Value in the Rectal Cancer Following Neoadjuvant Chemoradiotherapy: A Hypothesis-generating Study.微卫星不稳定性相关炎症标志物及其在新辅助放化疗后直肠癌中的预后价值：一项假说生成研究。
In Vivo. 2020 Jul-Aug;34(4):2119-2126. doi: 10.21873/invivo.12017.
2
Microsatellite instability and response to neoadjuvant chemoradiotherapy in rectal cancer: A systematic review and meta-analysis.微卫星不稳定性与直肠癌新辅助放化疗反应：系统评价和荟萃分析。
Surg Oncol. 2020 Sep;34:57-62. doi: 10.1016/j.suronc.2020.03.009. Epub 2020 Apr 2.
3
Predicting Pathological Complete Regression with Haematological Markers During Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.新辅助放化疗期间利用血液学标志物预测局部晚期直肠癌的病理完全缓解
Anticancer Res. 2018 Dec;38(12):6905-6910. doi: 10.21873/anticanres.13067.
4
Systemic Inflammatory Response After Preoperative Chemoradiotherapy Can Affect Oncologic Outcomes in Locally Advanced Rectal Cancer.术前放化疗后的全身炎症反应会影响局部晚期直肠癌的肿瘤学结局。
Anticancer Res. 2017 Mar;37(3):1459-1465. doi: 10.21873/anticanres.11470.
5
Systemic Inflammatory Response Following Preoperative Chemoradiotherapy Can Affect Oncologic Outcomes in MSI-H/dMMR Rectal Cancer.术前放化疗后的全身炎症反应会影响微卫星高度不稳定/错配修复缺陷型直肠癌的肿瘤学结局。
Chonnam Med J. 2024 May;60(2):105-112. doi: 10.4068/cmj.2024.60.2.105. Epub 2024 May 24.
6
Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy.中性粒细胞与淋巴细胞比值在新辅助放化疗治疗局部晚期直肠癌中的预后作用
Med Sci Monit. 2017 Jan 19;23:315-324. doi: 10.12659/msm.902752.
7
Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in rectal cancer patients following neoadjuvant chemoradiotherapy.新辅助放化疗后直肠癌患者的基线中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值
Tumori. 2019 Oct;105(5):434-440. doi: 10.1177/0300891618792476. Epub 2018 Aug 17.
8
Systemic inflammation-based predictors of pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients.局部进展期直肠癌患者新辅助放化疗病理反应的基于全身炎症反应的预测因子。
J Cancer Res Ther. 2022 Apr;18(2):438-444. doi: 10.4103/jcrt.jcrt_1807_21.
9
Elevated platelet count as predictor of recurrence in rectal cancer patients undergoing preoperative chemoradiotherapy followed by surgery.血小板计数升高作为接受术前放化疗后手术的直肠癌患者复发的预测指标。
Int Surg. 2015 Feb;100(2):199-207. doi: 10.9738/INTSURG-D-13-00178.1.
10
Prognostic value of changes in serum carcinoembryonic antigen levels for preoperative chemoradiotherapy response in locally advanced rectal cancer.血清癌胚抗原水平变化对局部晚期直肠癌术前放化疗反应的预测价值。
World J Gastroenterol. 2020 Nov 28;26(44):7022-7035. doi: 10.3748/wjg.v26.i44.7022.
引用本文的文献
1
Pan-immune-inflammation in colon cancer: A prognostic biomarker and the role of tumor location in personalized care.结肠癌中的全免疫炎症：一种预后生物标志物及肿瘤位置在个性化治疗中的作用
World J Gastrointest Surg. 2025 Apr 27;17(4):101066. doi: 10.4240/wjgs.v17.i4.101066.
2
Correlation between mismatch repair and survival of patients with gastric cancer after 5-FU-based adjuvant chemotherapy.基于 5-FU 的辅助化疗后胃癌患者错配修复与生存的相关性。
J Gastroenterol. 2023 Jul;58(7):622-632. doi: 10.1007/s00535-023-01990-z. Epub 2023 Apr 10.
3
Predictive and prognostic value of inflammatory markers in locally advanced rectal cancer (PILLAR) - A multicentric analysis by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Study Group.局部晚期直肠癌炎症标志物的预测和预后价值（PILLAR）——意大利放射治疗与临床肿瘤学会（AIRO）胃肠研究组的多中心分析
Clin Transl Radiat Oncol. 2023 Jan 12;39:100579. doi: 10.1016/j.ctro.2023.100579. eCollection 2023 Mar.
4
Predictive and Prognostic Value of Oncogene Mutations and Microsatellite Instability in Locally-Advanced Rectal Cancer Treated with Neoadjuvant Radiation-Based Therapy: A Systematic Review and Meta-Analysis.基于新辅助放疗的局部晚期直肠癌中癌基因突变和微卫星不稳定性的预测及预后价值：一项系统评价和荟萃分析
Cancers (Basel). 2023 Feb 25;15(5):1469. doi: 10.3390/cancers15051469.
5
Microsatellite instability in rectal cancer: what does it mean? A study of two randomized trials and a systematic review of the literature.直肠癌中的微卫星不稳定性：意味着什么？两项随机试验研究和文献系统评价。
Histopathology. 2022 Sep;81(3):352-362. doi: 10.1111/his.14710. Epub 2022 Jul 14.
6
Meta-Analysis on the Neutrophil-Lymphocyte Ratio in Rectal Cancer Treated With Preoperative Chemoradiotherapy: Prognostic Value of Pre- and Post-Chemoradiotherapy Neutrophil-Lymphocyte Ratio.术前放化疗治疗直肠癌中性粒细胞与淋巴细胞比值的Meta分析：放化疗前后中性粒细胞与淋巴细胞比值的预后价值
Front Oncol. 2022 Feb 11;12:778607. doi: 10.3389/fonc.2022.778607. eCollection 2022.
本文引用的文献
1
Do microsatellite instability (MSI) and deficient mismatch repair (dMMR) affect the pathologic complete response (pCR) in patients with rectal cancer who received neoadjuvant treatment?微卫星不稳定性 (MSI) 和错配修复缺陷 (dMMR) 是否会影响接受新辅助治疗的直肠癌患者的病理完全缓解 (pCR)？
Updates Surg. 2020 Mar;72(1):73-82. doi: 10.1007/s13304-019-00697-2. Epub 2019 Dec 20.
2
Microsatellite Instability and Survival in Stage II Colorectal Cancer: A Systematic Review and Meta-analysis.微卫星不稳定性与 II 期结直肠癌的生存：系统评价和荟萃分析。
Anticancer Res. 2019 Dec;39(12):6431-6441. doi: 10.21873/anticanres.13857.
3
Complete response in patients with locally advanced rectal cancer after neoadjuvant treatment with nivolumab.纳武单抗新辅助治疗后局部晚期直肠癌患者的完全缓解
Oncoimmunology. 2019 Sep 19;8(12):e1663108. doi: 10.1080/2162402X.2019.1663108. eCollection 2019.
4
Predicting Pathological Complete Regression with Haematological Markers During Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.新辅助放化疗期间利用血液学标志物预测局部晚期直肠癌的病理完全缓解
Anticancer Res. 2018 Dec;38(12):6905-6910. doi: 10.21873/anticanres.13067.
5
Microsatellite Instability (MSI) as an Independent Predictor of Pathologic Complete Response (PCR) in Locally Advanced Rectal Cancer: A National Cancer Database (NCDB) Analysis.微卫星不稳定性（MSI）作为局部晚期直肠癌病理完全缓解（PCR）的独立预测因子：国家癌症数据库（NCDB）分析。
Ann Surg. 2020 Apr;271(4):716-723. doi: 10.1097/SLA.0000000000003051.
6
Baseline neutrophil-to-lymphocyte ratio (NLR) and derived NLR could predict overall survival in patients with advanced melanoma treated with nivolumab.基线中性粒细胞与淋巴细胞比值（NLR）及其衍生的 NLR 可预测接受纳武利尤单抗治疗的晚期黑色素瘤患者的总生存期。
J Immunother Cancer. 2018 Jul 16;6(1):74. doi: 10.1186/s40425-018-0383-1.
7
Pretreatment Inflammatory Indexes as Prognostic Predictors for Survival in Colorectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy.新辅助放化疗治疗的结直肠癌患者的预处理炎症指标作为生存预后预测因子。
Sci Rep. 2018 Feb 14;8(1):3044. doi: 10.1038/s41598-018-21093-7.
8
Change in Neutrophil-to-lymphocyte ratio (NLR) in response to immune checkpoint blockade for metastatic renal cell carcinoma.中性粒细胞与淋巴细胞比值（NLR）对转移性肾细胞癌免疫检查点阻断的反应变化。
J Immunother Cancer. 2018 Jan 22;6(1):5. doi: 10.1186/s40425-018-0315-0.
9
Chemoradiation-Induced Alteration of Programmed Death-Ligand 1 and CD8 Tumor-Infiltrating Lymphocytes Identified Patients With Poor Prognosis in Rectal Cancer: A Matched Comparison Analysis.化疗放疗诱导的程序性死亡配体1和CD8肿瘤浸润淋巴细胞改变可识别直肠癌预后不良患者：一项配对比较分析
Int J Radiat Oncol Biol Phys. 2017 Dec 1;99(5):1216-1224. doi: 10.1016/j.ijrobp.2017.07.004.
10
Redefining the Positive Circumferential Resection Margin by Incorporating Preoperative Chemoradiotherapy Treatment Response in Locally Advanced Rectal Cancer: A Multicenter Validation Study.将术前放化疗治疗反应纳入局部进展期直肠癌的阳性环周切缘定义：多中心验证研究。
Cancer Res Treat. 2018 Apr;50(2):506-517. doi: 10.4143/crt.2016.607. Epub 2017 May 24.
Zotero 插件