Rutkove S B, Kothari M J, Raynor E M, Levy M L, Fadic R, Nardin R A
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Muscle Nerve. 1997 Oct;20(10):1236-41. doi: 10.1002/(sici)1097-4598(199710)20:10<1236::aid-mus5>3.0.co;2-d.
As proximal nerves are relatively spared in length-dependent, axonal polyneuropathy, we theorized that a sural/radial amplitude ratio (SRAR) might be a sensitive indicator of mild polyneuropathy. In this study, sural amplitudes and SRARs in patients with signs of mild axonal polyneuropathy were compared to those of normal, age-matched control subjects. Sural and radial sensory responses were measured in a standard fashion in all subjects. Thirty polyneuropathy patients had an average SRAR of 0.29 as compared to 0.71 for the 30 normal subjects. An SRAR of less than 0.40 was a strong predictor of axonal polyneuropathy, with 90% sensitivity and 90% specificity, as compared to an absolute sural amplitude of less than 6.0 microV, which had sensitivity of only 66%. Additionally, unlike the sural amplitude, the ratio did not vary significantly with age. We conclude that the SRAR is a sensitive, specific, age-independent electrodiagnostic test for mild axonal polyneuropathy.
由于在长度依赖性轴索性多发性神经病中近端神经相对较少受累，我们推测腓肠神经/桡神经波幅比值（SRAR）可能是轻度多发性神经病的一个敏感指标。在本研究中，将有轻度轴索性多发性神经病体征患者的腓肠神经波幅和SRAR与年龄匹配的正常对照受试者进行比较。所有受试者均以标准方式测量腓肠神经和桡神经感觉反应。30例多发性神经病患者的平均SRAR为0.29，而30例正常受试者为0.71。与绝对腓肠神经波幅小于6.0微伏相比，SRAR小于0.40是轴索性多发性神经病的有力预测指标，敏感性为90%，特异性为90%，而绝对腓肠神经波幅小于6.0微伏时敏感性仅为66%。此外，与腓肠神经波幅不同，该比值不会随年龄显著变化。我们得出结论，SRAR是一种用于轻度轴索性多发性神经病的敏感、特异且与年龄无关的电诊断测试。
