Misale Priyanka, Lepcha Anjali, Thomas Philip, Sebastian Swapna, Sebastian Tunny
Department of ENT Unit 4, Christian Medical College, Vellore, Tamil Nadu, India.
Department of Audiology, Christian Medical College, Vellore, Tamil Nadu, India.
Ann Indian Acad Neurol. 2020 May-Jun;23(3):296-302. doi: 10.4103/aian.AIAN_397_18. Epub 2020 Jun 10.
The objective of the study is to establish normative values of cortical evoked response audiometry (CERA) in a heterogeneous Indian population and correlate CERA threshold with pure tone audiometric (PTA) threshold values.
A prospective study was carried out on 31 volunteers ( = 62) who had no otological or neurological complaints. Two study groups were formed; Group 1 with individuals from 20 to 40 years (mean age of 29.1 years) and Group 2 with individuals from 41 to 60 years (mean age of 46.2 years). The latencies and amplitudes of the waves of P1, N1, and P2 at threshold and 70 dBnHL were measured.
Twenty-nine participants (94% of the ears) had CERA threshold within 20 dB of true behavioral threshold with only 6% having a difference of >20 dB with their PTA thresholds. There was a significant difference ( < 0.05) at 70 dB in amplitudes for waves P1, N1, and P2 at 2 kHz and additionally at 1 kHz for N1 between the two groups.
Normative values for CERA in a heterogeneous Indian population at 70 dB nHL using tone burst stimulus was found to have an average latency of 46.5, 90.1, and 155.5 ms for P1, N1, and P2, respectively. The average amplitude of P1 at 70 dB nHL was 4.3 μV, N1, was 6.5 μV and P2 was 3.2 μV. Hearing threshold obtained with CERA gave a good indication of the actual behavioral hearing threshold of the normal controls, and the age of an individual had a significant effect on the values obtained during CERA testing with N1 being significantly larger at 1 kHz and 2 kHz in older adults when compared to young adults.
本研究的目的是在印度异质人群中建立皮层诱发反应测听法(CERA)的正常值,并将CERA阈值与纯音听力测定(PTA)阈值进行关联。
对31名无耳科或神经科主诉的志愿者(共62耳)进行了一项前瞻性研究。形成了两个研究组;第1组为年龄在20至40岁之间(平均年龄29.1岁)的个体,第2组为年龄在41至60岁之间(平均年龄46.2岁)的个体。测量了阈值和70 dBnHL时P1、N1和P2波的潜伏期和波幅。
29名参与者(94%的耳朵)的CERA阈值在真实行为阈值的20 dB范围内,只有6%的人其CERA阈值与PTA阈值的差异>20 dB。两组之间在2 kHz时P1、N1和P2波以及在1 kHz时N1波的70 dB波幅存在显著差异(P<0.05)。
发现在印度异质人群中使用短纯音刺激在70 dB nHL时CERA的正常值,P1、N1和P2的平均潜伏期分别为46.5、90.1和155.5 ms。70 dB nHL时P1的平均波幅为4.3 μV,N1为6.5 μV,P2为3.2 μV。CERA获得的听力阈值能很好地反映正常对照组的实际行为听力阈值,并且个体年龄对CERA测试期间获得的值有显著影响,与年轻人相比,老年人在1 kHz和2 kHz时N1波幅明显更大。