Department of Audiology, All India Institute of Speech and Hearing, Mysore, Karnataka, 570006, India.
Behav Brain Funct. 2008 Mar 31;4:15. doi: 10.1186/1744-9081-4-15.
Present study investigated the relationship between speech identification scores in quiet and parameters of cortical potentials (latency of P1, N1, and P2; and amplitude of N1/P2) in individuals with auditory neuropathy.
Ten individuals with auditory neuropathy (five males and five females) and ten individuals with normal hearing in the age range of 12 to 39 yr participated in the study. Speech identification ability was assessed for bi-syllabic words and cortical potentials were recorded for click stimuli.
Results revealed that in individuals with auditory neuropathy, speech identification scores were significantly poorer than that of individuals with normal hearing. Individuals with auditory neuropathy were further classified into two groups, Good Performers and Poor Performers based on their speech identification scores. It was observed that the mean amplitude of N1/P2 of Poor Performers was significantly lower than that of Good Performers and those with normal hearing. There was no significant effect of group on the latency of the peaks. Speech identification scores showed a good correlation with the amplitude of cortical potentials (N1/P2 complex) but did not show a significant correlation with the latency of cortical potentials.
Results of the present study suggests that measuring the cortical potentials may offer a means for predicting perceptual skills in individuals with auditory neuropathy.
本研究调查了听神经病患者在安静环境下的言语识别得分与皮质电位参数（P1、N1 和 P2 的潜伏期；N1/P2 的振幅）之间的关系。
10 名听神经病患者（男 5 名，女 5 名）和 10 名年龄在 12 至 39 岁之间的听力正常者参与了这项研究。采用双音节词评估言语识别能力，并对 click 刺激记录皮质电位。
结果表明，在听神经病患者中，言语识别得分明显低于听力正常者。根据言语识别得分，将听神经病患者进一步分为“表现良好者”和“表现不佳者”两组。观察到表现不佳者的 N1/P2 平均振幅明显低于表现良好者和听力正常者。组间潜伏期无显著影响。言语识别得分与皮质电位振幅（N1/P2 复合波）呈良好相关性，但与皮质电位潜伏期无显著相关性。
本研究结果表明，测量皮质电位可能为预测听神经病患者的知觉技能提供一种手段。
