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糖码偶联海藻酸盐：在 GERD 和感染的同时预防中取得战略突破的创新平台。

Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Infection.

机构信息

Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Drug Des Devel Ther. 2020 Jun 17;14:2405-2412. doi: 10.2147/DDDT.S255611. eCollection 2020.

DOI:10.2147/DDDT.S255611
PMID:32606607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7306573/
Abstract

INTRODUCTION

Currently, gastroesophageal reflux disease (GERD) is one of the most ubiquitous problems in clinical practice. An antacid-alginate combination (under the trade name Gaviscon) is a natural-based product that effectively suppresses GERD. This product acts via the formation of viscous gel that floats on the top of the gastric content. On the other hand, efficient management of infection with minimal side effects is an important goal for gastroenterologists. Furthermore, some -positive patients suffer from GERD.

METHODS

Here, we present the results of investigations on alginate conjugated to sugar codes in order to find initial clues regarding the potential ability of this conjugate in the simultaneous prophylaxis of GERD and infection in an in vitro assay.

RESULTS

It is noteworthy that our results reveal that sugar codes conjugated alginate considerably decrease (approximately 74%) the adhesion of to gastric epithelial cells in vitro. Moreover, surprisingly after conjugation of sugar codes, alginate can maintain its ability to create gel. Our results demonstrate that alginate conjugated to sugar codes is not cytotoxic.

CONCLUSION

The preparation of these conjugates can be regarded as the first step to establish a new roadmap for the simultaneous prevention of GERD and infection in future studies on in vivo models.

摘要

简介

目前，胃食管反流病（GERD）是临床实践中最常见的问题之一。一种抗酸-藻酸盐的组合（商品名 Gaviscon）是一种天然的产品，可以有效地抑制 GERD。该产品通过形成漂浮在胃内容物顶部的粘性凝胶起作用。另一方面，以最小的副作用有效地管理感染是胃肠病学家的一个重要目标。此外，一些阳性患者患有 GERD。

方法

在这里，我们介绍了糖码与藻酸盐结合的研究结果，以便在体外试验中找到该结合物在同时预防 GERD 和感染方面的潜在能力的初步线索。

结果

值得注意的是，我们的结果表明，糖码结合的藻酸盐可显著减少（约 74%）体外 对胃上皮细胞的粘附。此外，令人惊讶的是，糖码结合后，藻酸盐仍能保持形成凝胶的能力。我们的结果表明，糖码结合的藻酸盐没有细胞毒性。

结论

这些缀合物的制备可以被视为在未来的体内模型研究中建立同时预防 GERD 和感染的新路线图的第一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/016d7f4e3fc1/DDDT-14-2405-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/dce77c2ace4a/DDDT-14-2405-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/d1fcacf41907/DDDT-14-2405-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/122e447bdd85/DDDT-14-2405-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/e2911317a546/DDDT-14-2405-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/c2abc39102cd/DDDT-14-2405-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/016d7f4e3fc1/DDDT-14-2405-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/dce77c2ace4a/DDDT-14-2405-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/d1fcacf41907/DDDT-14-2405-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/122e447bdd85/DDDT-14-2405-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/e2911317a546/DDDT-14-2405-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/c2abc39102cd/DDDT-14-2405-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f89c/7306573/016d7f4e3fc1/DDDT-14-2405-g0006.jpg

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