Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
Int J Nanomedicine. 2020 Jun 17;15:4257-4273. doi: 10.2147/IJN.S239548. eCollection 2020.
In recent years, it has been found that exosomes can be used as nanocarriers, which can be used in the treatment of tumors by carrying contents. The exosomes are derived from the secretion of the organism's own cells and are characterized by a phospholipid bilayer structure and a small particle size. These characteristics guarantee that the exosomes can carry a wide range of tumor drugs, deliver the drug to the cancer, and reduce or eliminate the tumor drug band. The toxic side effects were significantly eliminated; meanwhile, the therapeutic effects of the drug on the tumor were remarkably improved. This paper reviewed the strategies and drugs presented by different scholars for the treatment of tumors based on the drugs carried by exosomes.
近年来，人们发现外泌体可以作为纳米载体，通过携带内容物来治疗肿瘤。外泌体来源于机体自身细胞的分泌，具有磷脂双分子层结构和较小的粒径。这些特性保证了外泌体可以携带广泛的肿瘤药物，将药物递送到癌症部位，并减少或消除肿瘤药物带的毒性副作用；同时，显著提高了药物对肿瘤的治疗效果。本文综述了不同学者基于外泌体携带的药物提出的治疗肿瘤的策略和药物。
