Joo Sung Woo, Yoon Woon, Jo Young Tak, Kim Harin, Kim Yangsik, Lee Jungsun
Medical Corps, Republic of Korea Navy 1st Fleet, Donghae, Republic of Korea.
Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Neuropsychiatr Dis Treat. 2020 Jun 22;16:1561-1570. doi: 10.2147/NDT.S254208. eCollection 2020.
Despite a large number of resting-state functional MRI (rsfMRI) studies in schizophrenia, current evidence on the abnormalities of functional connectivity (FC) of resting-state networks shows high variability, and the findings on recent-onset schizophrenia are insufficient compared to those on chronic schizophrenia.
We performed a rsfMRI in 46 patients with recent-onset schizophrenia and 22 healthy controls. Group independent component brainmap and dual regression were performed for voxel-wise comparisons between the groups. Correlation of the symptom severity, cognitive function, duration of illness, and a total antipsychotics dose with FC was evaluated with Spearman's rho correlation.
The patient group had areas with a significantly decreased FC compared to that of the control group in which it existed in the left supplementary motor cortex and supramarginal gyrus (the executive control network) and the right postcentral gyrus (the auditory network). The patient group had a significant correlation of the total antipsychotics dose with the FC of the cluster in the left supplementary motor cortex in the executive control network.
Patients with recent-onset schizophrenia have decreased FC of the executive control and auditory networks compared to healthy controls.
尽管针对精神分裂症进行了大量静息态功能磁共振成像（rsfMRI）研究，但目前关于静息态网络功能连接（FC）异常的证据显示出高度变异性，且与慢性精神分裂症相比，近期发病精神分裂症的研究结果尚不充分。
我们对46例近期发病的精神分裂症患者和22名健康对照者进行了rsfMRI检查。采用组独立成分脑图谱和双回归分析对两组进行体素水平比较。采用Spearman等级相关分析评估症状严重程度、认知功能、病程及抗精神病药物总剂量与FC的相关性。
与对照组相比，患者组存在FC显著降低的区域，这些区域位于左侧辅助运动皮层和缘上回（执行控制网络）以及右侧中央后回（听觉网络）。患者组抗精神病药物总剂量与执行控制网络中左侧辅助运动皮层簇的FC存在显著相关性。
与健康对照者相比，近期发病的精神分裂症患者的执行控制网络和听觉网络的FC降低。
