LncRNA Promotes Expression by Adsorbing to Suppress Nasopharyngeal Carcinoma Cell Progression.

BACKGROUND

Recently, long non-coding RNAs (lncRNAs) have been elucidated to play essential roles in cancers, and the recognition of lncRNA expression patterns in nasopharyngeal carcinoma (NPC) may be helpful for indicating novel mechanisms underlying NPC carcinogenesis. Herein, we conducted this study to probe into the function of lncRNA in NPC progression with the involvement of () and actin-binding LIM protein 1 ().

MATERIALS AND METHODS

In silico analysis screened differentially expressed genes and miRNAs in NPC and predicted potential mechanisms. expression was detected in NPC tissues and cells. The gain-and-loss function assays were performed to explore the effects of lncRNA ZNF667-AS1 and in NPC cell biological behaviors. In vivo experiments were further conducted to confirm the in vitro results.

RESULTS

In silico analysis predicted that was diminished in NPC, which may downregulate through sponging . was poorly expressed in NPC tissues and cells, and overexpression of inhibited growth of NPC cells. competitively bound with , thereby upregulating . resulted in the promotion of NPC cell progression by suppressing . Overexpression of or suppression of inhibited tumorigenicity of NPC cells in vivo.

CONCLUSION

This study highlights that lncRNA promotes expression by sponging to suppress NPC cell progression.