A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion.

作者信息

Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Taheri Mohammad, Samadian Mohammad

机构信息

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Front Mol Biosci. 2021 Dec 24;8:763338. doi: 10.3389/fmolb.2021.763338. eCollection 2021.

DOI:10.3389/fmolb.2021.763338

PMID:35004844

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8740132/

Abstract

MicroRNAs (miRNAs) have been shown to affect expression of several genes contributing in important biological processes. miR-1290 a member of this family with crucial roles in the carcinogenesis. This miRNA is transcribed from gene on chromosome 1p36.13. This miRNA has interactions with a number of mRNA coding genes as well as non-coding RNAs SOCS4, GSK3, BCL2, CCNG2, KIF13B, INPP4B, hMSH2, KIF13B, NKD1, FOXA1, IGFBP3, CCAT1, FOXA1, NAT1, SMEK1, SCAI, ZNF667-AS1, ABLIM1, Circ_0000629 and CDC73. miR-1290 can also regulate activity of JAK/STAT3, PI3K/AKT, Wnt/β-catenin and NF-κB molecular pathways. Most evidence indicates the oncogenic roles of miR-1290, yet controversial evidence also exists. In the present review, we describe the results of , animal and human investigations about the impact of miR-1290 in the development of malignancies.

摘要