Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Taheri Mohammad, Samadian Mohammad
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Mol Biosci. 2021 Dec 24;8:763338. doi: 10.3389/fmolb.2021.763338. eCollection 2021.
MicroRNAs (miRNAs) have been shown to affect expression of several genes contributing in important biological processes. miR-1290 a member of this family with crucial roles in the carcinogenesis. This miRNA is transcribed from gene on chromosome 1p36.13. This miRNA has interactions with a number of mRNA coding genes as well as non-coding RNAs SOCS4, GSK3, BCL2, CCNG2, KIF13B, INPP4B, hMSH2, KIF13B, NKD1, FOXA1, IGFBP3, CCAT1, FOXA1, NAT1, SMEK1, SCAI, ZNF667-AS1, ABLIM1, Circ_0000629 and CDC73. miR-1290 can also regulate activity of JAK/STAT3, PI3K/AKT, Wnt/β-catenin and NF-κB molecular pathways. Most evidence indicates the oncogenic roles of miR-1290, yet controversial evidence also exists. In the present review, we describe the results of , animal and human investigations about the impact of miR-1290 in the development of malignancies.
微小RNA（miRNA）已被证明会影响多个参与重要生物学过程的基因的表达。miR-1290是该家族的一员，在癌症发生过程中起关键作用。这种miRNA由位于1p36.13染色体上的基因转录而来。该miRNA与许多编码mRNA的基因以及非编码RNA SOCS4、GSK3、BCL2、CCNG2、KIF13B、INPP4B、hMSH2、KIF13B、NKD1、FOXA1、IGFBP3、CCAT1、FOXA1、NAT1、SMEK1、SCAI、ZNF667-AS1、ABLIM1、Circ_0000629和CDC73相互作用。miR-1290还可以调节JAK/STAT3、PI3K/AKT、Wnt/β-连环蛋白和NF-κB分子通路的活性。大多数证据表明miR-1290具有致癌作用，但也存在有争议的证据。在本综述中，我们描述了细胞、动物和人体研究中关于miR-1290对恶性肿瘤发生影响的结果。
