Li Kai-Ming, Xu Man-Hua, Wu Xia, He Wei-Min
Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610000, People's Republic of China.
Department of Ophthalmology, Affiliated Hospital of Southwest Medical University, Luzhou 646000, People's Republic of China.
Onco Targets Ther. 2020 Jun 17;13:5755-5761. doi: 10.2147/OTT.S242852. eCollection 2020.
This study aims to study the expression and role of IgG and IgG4 in orbital MALT lymphoma and to compare the characteristics of IgG4-related diseases.
Patients with orbital MALT lymphoma, treated in the West China Hospital of Sichuan University from 2012 to 2017, were enrolled in the current study. The immunological examination of the wax blocks of orbital masses was performed again and the expression level of IgG and IgG4 in pathological tissue was analyzed.
The results presented that the positive rates of IgG and IgG4 in the cases of orbital MALT lymphoma were 90.91% and 61.98% respectively, of which IgG4/IgG >40% accounted for 49.33%. The positive rates of IgG and IgG4 in relapse cases were 94.60% and 70.27% respectively, and IgG4/IgG >40% accounted for 42.31%. There was no significant change in the expression of IgG and IgG4 in cases of lymphoproliferation converting to MALT lymphoma whereas, in cases of MALT lymphoma postoperatively converting to lymphoproliferation, there was an increase in IgG and IgG4 expression, with the change of IgG4 being significant.
IgG and IgG4 have a high correlation in the pathogenesis of MALT lymphoma and may even play an important role in the transformation of MALT lymphoma into orbital lymphoid hyperplasia. Given the association of IgG4 with inflammation and tumors and as an important diagnostic indicator for IgG4-RD and IgG4-related ophthalmic diseases, IgG4 may play an important role in these diseases.
本研究旨在探讨IgG和IgG4在眼眶黏膜相关淋巴组织边缘区淋巴瘤（MALT淋巴瘤）中的表达及作用，并比较IgG4相关疾病的特征。
选取2012年至2017年在四川大学华西医院接受治疗的眼眶MALT淋巴瘤患者纳入本研究。对眼眶肿物蜡块进行再次免疫检查，分析病理组织中IgG和IgG4的表达水平。
结果显示，眼眶MALT淋巴瘤病例中IgG和IgG4的阳性率分别为90.91%和61.98%，其中IgG4/IgG>40%者占49.33%。复发病例中IgG和IgG4的阳性率分别为94.60%和70.27%，IgG4/IgG>40%者占42.31%。淋巴细胞增殖转化为MALT淋巴瘤的病例中，IgG和IgG4表达无明显变化；而MALT淋巴瘤术后转化为淋巴细胞增殖的病例中，IgG和IgG4表达增加，其中IgG4变化显著。
IgG和IgG4在MALT淋巴瘤发病机制中具有高度相关性，甚至可能在MALT淋巴瘤转化为眼眶淋巴组织增生过程中起重要作用。鉴于IgG4与炎症和肿瘤的关联，以及作为IgG4相关性疾病（IgG4-RD）和IgG4相关眼科疾病的重要诊断指标，IgG4可能在这些疾病中发挥重要作用。
