Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 05505, Korea.
Department of Nuclear Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 05505, Korea.
Medicina (Kaunas). 2022 Jun 17;58(6):818. doi: 10.3390/medicina58060818.
: Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) type is the most common subtype of the ocular adnexal lymphoma. Despite its excellent prognosis, some patients experience partial remission or progressive disease. We aimed to evaluate clinicopathologic differences in the treatment responder group by comparing complete remission (CR) and non-complete remission (non-CR). : This study retrospectively reviewed 48 patients who were diagnosed with ocular adnexal MALT lymphoma at Ulsan University Hospital between March 2002 and August 2018. Patients who were followed up for less than 6 months were excluded. Histologic and clinical features were analyzed. The patients were divided into two groups: CR and non-CR. : Among the 48 patients, 33 achieved CR and 15 achieved non-CR during the median follow-up period of 40.00 months (range, 7-109 months). In univariable analysis, more patients tend to undergo treatment in the CR group, and post-radiotherapy (post-RT) SUVmax, PET and serum lactate dehydrogenase (LDH) levels were higher in the non-CR group ( = 0.043, = 0.016, and = 0.042, respectively). In a multivariable analysis, only application of treatment, including radiotherapy or chemotherapy with immunotherapy, was related to CR (odd ratio 7.301, 95% confidence interval 1.273-41.862, = 0.026). In subgroup analysis according to the site of involvement, none of the variables were significant except for the post-RT SUVmax of PET and level of serum LDH in the non-conjunctiva group ( = 0.026, and = 0.037, respectively). Seven (14.6%) patients had a recurrence, and those with a recurring site other than the primary site had a higher Ki-67 labeling index, although it was not statistically significant (9.56% vs. 18.00%, = 0.095). : Although belonging to the early stages, the non-CR rate was high in patients with high serum LDH levels, and recurred patients had higher Ki-67. Thus, considering active treatment is recommended in this group of patients.
: 结外黏膜相关淋巴组织（MALT）型边缘区淋巴瘤是眼附属器淋巴瘤最常见的亚型。尽管预后良好，但部分患者仍会出现部分缓解或疾病进展。我们旨在通过比较完全缓解（CR）和非完全缓解（non-CR）来评估治疗反应者组的临床病理差异。: 本研究回顾性分析了 2002 年 3 月至 2018 年 8 月在蔚山大学医院诊断为眼附属器 MALT 淋巴瘤的 48 例患者。排除了随访时间少于 6 个月的患者。分析了组织学和临床特征。患者分为两组：CR 和 non-CR。: 在 48 例患者中，33 例在中位随访 40.00 个月（7-109 个月）期间达到 CR，15 例达到 non-CR。在单变量分析中，CR 组中更多的患者倾向于接受治疗，非 CR 组中治疗后 SUVmax、PET 和血清乳酸脱氢酶（LDH）水平更高（ = 0.043， = 0.016，和 = 0.042，分别）。在多变量分析中，只有治疗的应用，包括放疗或化疗联合免疫治疗，与 CR 相关（优势比 7.301，95%置信区间 1.273-41.862， = 0.026）。根据受累部位的亚组分析，除非结膜组的治疗后 SUVmax 和血清 LDH 水平外，其他变量均无统计学意义（ = 0.026，和 = 0.037，分别）。7 例（14.6%）患者复发，复发部位非原发部位的患者 Ki-67 标记指数较高，但无统计学意义（9.56%比 18.00%， = 0.095）。: 尽管属于早期阶段，但血清 LDH 水平较高的患者非 CR 率较高，且复发患者 Ki-67 较高。因此，建议对这组患者进行积极治疗。
