Ata Naim, Dal Kürşat, Kucukazman Metin, Yeniova Abdullah Ö, Karakaya Serdar, Unsal Oktay, Dagdeviren Murat, Akın Kadir O, Baser Salih, Beyan Esin, Ertugrul Derun T
Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey, Tel: +90 312 3569000.
Open Med (Wars). 2014 Sep 17;10(1):8-13. doi: 10.1515/med-2015-0002. eCollection 2015.
Diabetes mellitus is closely related to pancreas cancer. In this study we aimed to investigate the effect of hyperglycemia on tumor and inflammation markers, as well as pancreatic exocrine functions.
A total of 98 consecutive diabetic patients with poor glycemic control, and 50 healthy controls were included in the study. We measured hsCRP, erythrocyte sedimentation rate (ESR), CA19-9, CEA, amylase and lipase in addition to routine biochemistry tests, before and after euglycemia was achieved.
Fasting blood glucose, HbA1c, CA19-9, CEA, hsCRP, ESR, triglycerides, AST, ALT, GGT, ALP, total cholesterol and LDL-C levels decreased significantly with the regulation of glycemic control. Amylase and lipase levels increased with the regulation of glycemic control. After glycemic control, CA19-9 and CEA levels were still higher, whereas amylase and lipase levels were still lower in the diabetic group compared with the control group. Basal HbA1c showed significant correlation with CA19-9, CEA, amylase and lipase.
We propose to repeat observations of tumor markers after hyperglycemia is resolved, in order to avoid unnecessary invasive tests. Our data also suggest that pancreatic exocrine function was improved with lowering blood glucose in a short period of time.
糖尿病与胰腺癌密切相关。在本研究中，我们旨在探讨高血糖对肿瘤和炎症标志物以及胰腺外分泌功能的影响。
本研究共纳入98例血糖控制不佳的连续糖尿病患者和50例健康对照。在实现血糖正常前后，除常规生化检查外，我们还测量了超敏C反应蛋白（hsCRP）、红细胞沉降率（ESR）、糖类抗原19-9（CA19-9）、癌胚抗原（CEA）、淀粉酶和脂肪酶。
随着血糖控制的调节，空腹血糖、糖化血红蛋白（HbA1c）、CA19-9、CEA、hsCRP、ESR、甘油三酯、谷草转氨酶（AST）、谷丙转氨酶（ALT）、γ-谷氨酰转肽酶（GGT）、碱性磷酸酶（ALP）、总胆固醇和低密度脂蛋白胆固醇（LDL-C）水平显著降低。随着血糖控制的调节，淀粉酶和脂肪酶水平升高。血糖控制后，糖尿病组的CA19-9和CEA水平仍较高，而淀粉酶和脂肪酶水平仍低于对照组。基础HbA1c与CA19-9、CEA、淀粉酶和脂肪酶呈显著相关。
我们建议在高血糖得到解决后重复观察肿瘤标志物，以避免不必要的侵入性检查。我们的数据还表明，短期内降低血糖可改善胰腺外分泌功能。
