Bodoor Khaldon, Al-Qarqaz Firas, Heis Leen Al, Alfaqih Mahmoud A, Oweis Ashraf O, Almomani Rowida, Obeidat Motaz A
Department of Applied Biology, Jordan University of Science and Technology, Irbid, Jordan.
Department of Dermatology, Jordan University of Science and Technology, Irbid, Jordan.
Clin Cosmet Investig Dermatol. 2020 Jun 19;13:419-424. doi: 10.2147/CCID.S257647. eCollection 2020.
Pruritus is the most common symptom in patients with skin disease. Psoriasis and atopic dermatitis are clinically distinct inflammatory diseases. Interleukins are cytokines which play key roles in inflammatory signaling pathways.
Cross-sectional study was conducted among patients with psoriasis and atopic dermatitis: 59 psoriatic patients, 56 AD patients, and 49 matched healthy controls. Interleukins 4, 13, 31, 33 serum levels were assayed by ELISA and results were compared using SPSS. Itch severity and disease severity were measured and correlation with interleukin levels was determined using SPSS.
The serum levels of IL-4, -13, -31, -33 were elevated in atopic dermatitis patients compared to controls. Itch and disease severity were not correlated with elevated serum levels of these interleukins. In psoriasis, the levels of IL-4 and -31 were elevated compared to controls, whereas the levels of IL-13 and -33 were lower than controls. The levels of measured interleukins in psoriasis did not correlate with itch and disease severity.
IL-31 is the key mediator for pruritus in both AD and Ps patients. IL-4/31 axis and IL-33/13 axis play distinct roles in the pathogenesis of Atopic dermatitis and Psoriasis. Interleukin serum levels were not correlated with itch and disease severity in both conditions.
瘙痒是皮肤病患者最常见的症状。银屑病和特应性皮炎是临床上不同的炎症性疾病。白细胞介素是在炎症信号通路中起关键作用的细胞因子。
对银屑病和特应性皮炎患者进行横断面研究：59例银屑病患者、56例特应性皮炎患者和49例匹配的健康对照。采用酶联免疫吸附测定法（ELISA）检测血清白细胞介素4、13、31、33水平，并使用SPSS软件比较结果。测量瘙痒严重程度和疾病严重程度，并使用SPSS软件确定其与白细胞介素水平的相关性。
与对照组相比，特应性皮炎患者血清IL-4、-13、-31、-33水平升高。瘙痒和疾病严重程度与这些白细胞介素的血清水平升高无关。在银屑病中，与对照组相比，IL-4和-31水平升高，而IL-13和-33水平低于对照组。银屑病中测得的白细胞介素水平与瘙痒和疾病严重程度无关。
IL-31是特应性皮炎和银屑病患者瘙痒的关键介质。IL-4/31轴和IL-33/13轴在特应性皮炎和银屑病的发病机制中发挥不同作用。在这两种疾病中，白细胞介素血清水平与瘙痒和疾病严重程度均无关。
