Siniewicz-Luzeńczyk Katarzyna, Stańczyk-Przyłuska Anna, Zeman Krzysztof
Department of Pediatrics, Preventive Cardiology and Immunology, Medical University of Lodz, Poland. Head of Department: Prof. Krzysztof Zeman MD, PhD.
Postepy Dermatol Alergol. 2013 Oct;30(5):282-5. doi: 10.5114/pdia.2013.38356. Epub 2013 Oct 30.
Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by intense itch, typical localization and a specific image of skin lesions. Pathogenesis of pruritus in AD is not fully understood, but recent studies emphasize the role of interleukin-31 (IL-31). This relatively recently described cytokine is considered to be a potential mediator inducing pruritus in AD.
To assess the correlation of serum IL-31 level and the disease severity in children with AD.
Twenty-five children (16 girls and 9 boys) with AD aged from 4 months to 17 years (mean age: 4.2 years) were enrolled in the study. Disease severity in children with AD was assessed using the SCORAD (Severity SCORing of Atopic Dermatitis) index. Serum IL-31 levels were measured using ELISA with standard kits from EIAab R&D Systems.
Serum IL-31 level was significantly higher in AD children than in healthy children. There was no statistic correlation between serum IL-31 level and the disease severity or itch intensity.
The disease severity and itch intensity do not correlate with serum IL-31 level in children with atopic dermatitis.
特应性皮炎（AD）是一种慢性炎症性皮肤病，其特征为剧烈瘙痒、典型的发病部位及特定的皮肤损害表现。AD瘙痒的发病机制尚未完全明确，但近期研究强调了白细胞介素-31（IL-31）的作用。这种相对较新发现的细胞因子被认为是AD中诱导瘙痒的潜在介质。
评估AD患儿血清IL-31水平与疾病严重程度之间的相关性。
本研究纳入了25例年龄在4个月至17岁（平均年龄：4.2岁）的AD患儿（16例女孩，9例男孩）。采用特应性皮炎严重程度评分（SCORAD）指数评估AD患儿的疾病严重程度。使用艾美捷科技有限公司研发系统的标准试剂盒，通过酶联免疫吸附测定（ELISA）法检测血清IL-31水平。
AD患儿的血清IL-31水平显著高于健康儿童。血清IL-31水平与疾病严重程度或瘙痒强度之间无统计学相关性。
特应性皮炎患儿的疾病严重程度和瘙痒强度与血清IL-31水平无关。
