Spencer J, Cerf-Bensussan N, Jarry A, Brousse N, Guy-Grand D, Krajewski A S, Isaacson P G
Department of Histopathology, University College and Middlesex School of Medicine, London, England.
Am J Pathol. 1988 Jul;132(1):1-5.
Enteropathy-associated T cell lymphoma (EATCL; malignant histiocytosis of the intestine) arises in patients with enteropathy, which in some cases is known to be a result of gluten sensitivity. The lymphoma arises in the intestine, where it may remain localized, although eventual dissemination is the rule. Intraepithelial tumour cells often are seen at the mucosal tumor margin. These features suggest that EATCL may be a tumor of intraepithelial lymphocytes. A monoclonal antibody (HML-1) has been produced recently that recognizes the entire intraepithelial lymphocyte population and 50% of lamina propria T cells but very few cells outside the mucosa. Immunocytochemistry has shown that all cases of enteropathy-associated T cell lymphoma studied are HML-1 positive and all peripheral T cell lymphomas and mucosal B cell lymphomas are HML-1 negative. This suggests strongly that EATCL is a tumor of mucosal T cells, possibly the intraepithelial T cell component.
肠病相关T细胞淋巴瘤（EATCL；肠道恶性组织细胞增多症）发生于患有肠病的患者，在某些情况下，已知肠病是麸质敏感性的结果。淋巴瘤起源于肠道，在肠道中它可能局限于局部，尽管最终扩散是常见情况。在黏膜肿瘤边缘常可见上皮内肿瘤细胞。这些特征提示EATCL可能是上皮内淋巴细胞肿瘤。最近制备了一种单克隆抗体（HML-1），它能识别整个上皮内淋巴细胞群体以及50%的固有层T细胞，但黏膜外的细胞很少。免疫细胞化学显示，所有研究的肠病相关T细胞淋巴瘤病例均为HML-1阳性，而所有外周T细胞淋巴瘤和黏膜B细胞淋巴瘤均为HML-1阴性。这强烈提示EATCL是黏膜T细胞肿瘤，可能是上皮内T细胞成分。
