Gaulard P, Henni T, Marolleau J P, Haioun C, Henni Z, Voisin M C, Divine M, Goossens M, Farcet J P, Reyes F
Département de Pathologie Tissulaire et Cellulaire, CHU Henri Mondor, Creteil, France.
Cancer. 1988 Aug 15;62(4):705-10. doi: 10.1002/1097-0142(19880815)62:4<705::aid-cncr2820620410>3.0.co;2-z.
Lymphomatoid granulomatosis (LG) and polymorphic reticulosis (PR), originally described as distinct entities, now are considered as a single disease process. Common histopathologic features include necrosis, vasculitis, and a granulomatous infiltrate. Such features have led to consider lymphomatoid granulomatosis as a systemic vasculitis; alternatively the possible emergence of an overt lymphoma has suggested that it could be a lymphoproliferative process. To investigate this later hypothesis, the authors analyzed the cellular infiltrate of tissue specimens from two patients with histologic features of LG. The analysis included the study of T-cell antigen expression and DNA rearrangement of the beta T-cell receptor gene. In one patient, the T-cell phenotype of infiltrating cells was abnormal because of antigen loss. In both patients, the cells contained rearranged DNA indicating the presence of a clonal T-cell proliferation. It is concluded that some cases of LG and PR, if not all, are related to a neoplastic T-cell lymphoproliferative disorder.
淋巴瘤样肉芽肿病（LG）和多形性网状细胞增多症（PR），最初被描述为不同的实体，现在被认为是单一的疾病过程。常见的组织病理学特征包括坏死、血管炎和肉芽肿浸润。这些特征导致将淋巴瘤样肉芽肿病视为一种系统性血管炎；或者，明显淋巴瘤的可能出现表明它可能是一种淋巴细胞增殖过程。为了研究后一种假设，作者分析了两名具有LG组织学特征的患者组织标本的细胞浸润情况。分析包括T细胞抗原表达和βT细胞受体基因的DNA重排研究。在一名患者中，由于抗原丢失，浸润细胞的T细胞表型异常。在两名患者中，细胞均含有重排的DNA，表明存在克隆性T细胞增殖。结论是，部分LG和PR病例（如果不是全部的话）与肿瘤性T细胞淋巴细胞增殖性疾病有关。
